Results 71 to 80 of about 423,085 (312)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Evaluating the Anti-Osteoporotic Potential of Mediterranean Medicinal Plants: A Review of Current Evidence

Pharmaceuticals
Background: Bones are biological reservoirs for minerals and cells, offering protection to the other organs and contributing to the structural form of the body.
Alhareth Abdulraheem Al-Ajalein, Nurul ‘Izzah Ibrahim, Mh Busra Fauzi, Sabarul Afian Mokhtar, Isa Naina Mohamed, Ahmad Nazrun Shuid, Norazlina Mohamed   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

VIBOT Day: un exemple de bones pràctiques universitat-empresa

, 2018
Presentació de l’activitat VIBOT Day, un exemple de bones pràctiques referent a la relació universitat–empresa, en el marc dels estudis del màster Erasmus Mundus VIBOT de la Universitat de Girona.
Oliver i Malagelada, Arnau, Martí Bonmatí, Joan, Cufí i Solé, Xavier, Freixenet i Bosch, Jordi, Salvi, Joaquim, Martí Marly, Robert, Lladó Bardera, Xavier   +6 more
core  

Functionalizing NaGdF₄:Yb,Er Upconverting Nanoparticles with Bone-Targeting Phosphonate Ligands: Imaging and In Vivo Biodistribution

Inorganics, 2019
Lanthanide-doped upconverting nanoparticles (UCNPs) transform near infrared light (NIR) into higher-energy UV and visible light by multiphotonic processes.
Silvia Alonso-de Castro, Emmanuel Ruggiero, Aitor Lekuona Fernández, Unai Cossío, Zuriñe Baz, Dorleta Otaegui, Vanessa Gómez-Vallejo, Daniel Padro, Jordi Llop, Luca Salassa   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of the long bone microstructure of two southern African marine birds, the Cape gannet (Morus capensis) and the African penguin (Spheniscus demersus) with respect to their aquatic adaptations

, 2013
The Cape gannet (Morus capensis) and the African penguin (Spheniscus demersus) have distinct aquatic adaptations for locomotion. The gannet, which is an efficient flying bird, uses both fore- and hind limbs to propel itself under water. On the other hand,
Dabee, Vidushi Prema
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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Ancestry of Brudder Bones

, 1879
Text document page 697-698 of Harper\u27s New Monthly Magazine Volume LVIII December, 1878-May 1879 excerpt from the Article "The Ancestry of Brudder Bones by Olive Long talking about minstrels, black facePages of Article ...
Olive Long
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Michael Connelly Interview: 9/11, City of Bones, and Lost Light [PDF]

, 2015
An interview with American crime author Michael Connelly, exploring the role of crime narratives as outlets for critical engagement with the politics of the war on terror and the associated neoconservative narrativising of 9/11.
Davies, C.
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