Results 81 to 90 of about 970,203 (307)

Ethnochemistry in the Dogon country (Mali, 11th-18th century)

Afrique Archéologie Arts, 2015
Les méthodes analytiques de la biogéochimie s’appliquent depuis plusieurs dizaines d’années aux études archéologiques. L’une des questions majeures posées par cette approche reste la conservation des signaux biogéochimiques pendant la phase taphonomique.
Anne-France Maurer, Alain Person, Antoine Zazzo, Élise Dufour, Mathieu Sebilo, Vincent Balter, Florence Lecornec, Valery Zeitoun, Marc de Rafélis, Annette Schmidt, Rogier Bedaux   +10 more
doaj   +1 more source

Effect of space flight on sodium, copper, manganese and magnesium content in the skeletal bones [PDF]

Sodium content decreased in the human skeletal bones and rose in the rat bones following space flight. In man copper content rose in the femoral bone and decreased in the vertebral body and the sternum, but was unchanged in the rest of the bones ...
Kolesnik, A. G., Komissarova, N. A., Prokhonchukov, A. A., Shakhunov, B. A., Taitsev, V. P., Zhizhina, V. A.   +5 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

First successful DNA isolation and profiling from bone using an approach that is non-destructive toward bone surface

Archives of Forensic Medicine and Criminology, 2016
Commonly used destructive DNA isolation techniques consist of pulverization which leads to the complete destruction of smaller bones or irreversible damage to larger bones through the cutting of extensive fragments.
Dominika Pluta, Arleta Lebioda, Anna Jonkisz, Tadeusz Dobosz   +3 more
doaj   +1 more source

Relational Reasoning Network (RRN) for Anatomical Landmarking

, 2019
Accurately identifying anatomical landmarks is a crucial step in deformation analysis and surgical planning for craniomaxillofacial (CMF) bones. Available methods require segmentation of the object of interest for precise landmarking.
Bagci, Ulas, Han, Wade W., Lee, Janice S., Liberton, Denise K., McIntosh, Mary, Sincan, Murat, Torosdagli, Neslisah, Verma, Payal   +7 more
core  

New Radiocarbon Dates from the Sanders Site (41LR2), Lamar County, Texas [PDF]

, 2017
Recent archaeological investigations at the West Mound at the Sanders site (41LR2), on the Red River in Lamar County, Texas, disclosed substantial archaeological deposits associated with a burned clay floor to an ancestral Caddo structure in the mound. A
Perttula, Timothy K.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Vise to hold bones or other irregular objects [PDF]

, 1972
Vise with stationary vee-shaped jaw and segmented notched jaw for holding irregular shaped objects is described. Operation of the device and specific application to holding bones are explained.
Dowell, R. H.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source