Results 111 to 120 of about 3,968,106 (236)

Timing of ACL injuries during elite male football (soccer) matches—Impact of player position, substitutes, contact mechanisms, possession status and situational pattern: An analysis of 369 ACL injuries

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To document the timing of anterior cruciate ligament (ACL) injuries according to match minute and effective minutes played during football matches, considering player position, substitutions, contact mechanism, possession status and situational pattern.
Matthew Buckthorpe, Stefano Di Paolo, Alberto Grassi, Filippo Toserelli, Francesco Della Villa   +4 more
wiley   +1 more source

Limited correlation between clinical failure and MRI graft status in the setting of revision anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To investigate whether clinically failed anterior cruciate ligament (ACL) reconstructions can be accurately identified using magnetic resonance imaging (MRI). Methods This prospective case series included 81 patients (mean age 33.5 ± 11.9 years, 50.6% male) with clinically failed ACL reconstructions defined by Lachman ≥ Grade 2, Pivot ...
Mikaeil Bakhshi, Anke Lux, Maximilian Michael Mueller, Nico Hinz, Dariusch Arbab, Karl‐Heinz Frosch, Ralph Akoto, Lena Eggeling   +7 more
wiley   +1 more source

Reduced patella medialization in valgus and varus knees using a KA‐optimized femoral component in kinematically aligned TKA

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Patellofemoral complications after total knee arthroplasty (TKA) are linked to femoral component design and trochlear alignment. This study compared the effects of a kinematically aligned (KA)‐optimized femoral component versus a standard design on patellofemoral kinematics, contact mechanics and quadriceps function, using native knee ...
Johanna‐Maria Simon, Tara Mauritia Siedow, Christoph Thorwächter, Hannes Traxler, Katharina Kirchhoff, Felix Endres, Boris Michael Holzapfel, Peter Ernst Müller, Thomas Richard Niethammer   +8 more
wiley   +1 more source

7 T MRI Connectivity‐Guided Reprogramming Improves Deep Brain Stimulation Motor Outcome in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD). Using 7‐Tesla (7 T) MRI connectivity analysis to visualize the patient‐specific STN motor subdivision, we hypothesize that reprogramming patients who are stimulated outside of this subdivision can improve their ...
Yarit Wiggerts, Annabel van der Weide, Rick Schuurman, Pepijn van den Munckhof, Rob MA de Bie, Martijn Beudel, Maarten Bot   +6 more
wiley   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Sensing in Sacral Neuromodulation: Objective, Individualized Stimulation Response Thresholds Directly From the Lead

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objectives Sacral neuromodulation (SNM) therapy today relies on visually observed motor responses (e.g., anal bellows contraction, toe flexion) and subjective patient feedback (pelvic region sensations) to optimize lead placement and perform device programming.
Colin Goudelocke, Henry Ruiz, Charles R. Powell, David Sheyn, Brian J. Linder, Ketul Shah, Gustavo Villegas, Joseph Henderson, Anne G. Sammarco, Sarah J. Offutt, David U.J. Keller, Katie C. Bittner, Hank Bink, Ivan Merlo, Julia P. Slopsema, Lisa Jungbauer Nikolas   +15 more
wiley   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Betulinic Acid Counteracts Statin‐Induced PCSK9 Upregulation Through FXR/SHP‐Associated Signaling

Phytotherapy Research, EarlyView.
Betulinic acid attenuates atorvastatin‐induced increases in PCSK9 expression and secretion while maintaining or increasing LDLR expression in hepatocyte‐derived cells. Mechanistic studies support the involvement of FXR/SHP signaling and show increased SHP–SREBP2 association.
Chan‐Woong Park, Mingoo Bae, Pureum Kang, Na Young Lee, Ja Hyun Koo, Young Hee Choi, Young‐Won Chin   +6 more
wiley   +1 more source

Training on the quadriceps of individuals with rheumatoid arthritis: A systematic review and meta‐analysis

Rheumatology &Autoimmunity, EarlyView.
Physical training significantly improves quadriceps strength in patients with rheumatoid arthritis. No serious adverse events were reported. Abstract Background Rheumatoid arthritis is a chronic, systemic disease in which patients can benefit from physical exercise.
Mariana Laís Boaretto, Diego Francis Saraiva Rodriguez, Dartel Ferrari de Lima, Cristiane Buzanello Donin, Alberito Rodrigo de Carvalho, Márcia Rosângela Buzanello, Gladson Ricardo Flor Bertolini   +6 more
wiley   +1 more source

Synergistic Toxicity of Low‐Concentration Metal Mixture on Male Rats: Reproductive, Renal, and Hepatic Effects

Environmental Toxicology, EarlyView.
ABSTRACT Mining plays a crucial role in economic development, but improper management can lead to severe environmental degradation. Particularly for iron ore, mining generates vast amounts of tailings often stored in unstable dams. This study aims to investigate the toxicological impacts of environmentally relevant concentrations of metals mixture ...
Kalinka Helóra Gomes de Almeida, Thalita Tofanin Sargiani D'Assumpção, Ana Priscila Gomes Silva, Carolina Rocha Moreira de Oliveira, Tailisi Hoppe Trevizani, Rubens Cesar Lopes Figueira, Lucas Buruaem Moreira, Juliana Elaine Perobelli   +7 more
wiley   +1 more source