Results 201 to 210 of about 3,884,723 (284)

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source

Heat Stress, Indoor Microclimate, and Lactation Feed Intake in Commercial Mediterranean Sows: Parity Effects and a Daily Resolution Predictive Model. [PDF]

Life (Basel)
Fotos L, Pourlis A, Valasi E, Papakonstantinou GI, Kousenidis K, Sougias A, Tsegas G, Chourdakis E, Tsiropoulos Z, Michailidou AV, Vlachocostas C, Papatsiros VG.   +11 more
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

A transdiagnostic approach to non-motor symptoms in Parkinson's disease: exploring internalizing, bipolar spectrum, and impulsive compulsive behavior profiles via cluster analysis. [PDF]

Front Aging Neurosci
Şahin AB, Mahmoudi M, Kadandır Y, Öztürkmen İM, Özaşik ES, Gök R, Seyidoğlu MN, Öztosun Ç, Öztop Çakmak Ö, Yalçın Çakmaklı G, Özer FF, Yapici Eser H.   +11 more
europepmc   +1 more source

Iterating bonferroni bounds

A general method is presented for generating improved Bonferroni bounds whenever an improvement on Boole's inequality holds.Bonferroni ...
Hoppe, Fred M.
core  

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Integrating biosafety and osteogenic efficacy: a translational pathway of fluorinated porcine-derived hydroxyapatite for bone regeneration. [PDF]

Front Bioeng Biotechnol
Lin T, Liu Y, Yu Z, Liu C, Feng J, Mai M, Guo Z, Yang X, Yan Y, Wu F, Wang Z, Su M, Xie L, Wu S, Chen Z.   +14 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

The influence of age in the progression from pre-myopia to myopia onset: a 1 year retrospective analysis. [PDF]

Front Med (Lausanne)
Wang S, Huang K, He X, Wang Z.
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source