Results 51 to 60 of about 157,567 (254)

Increased Osteoblast GαS Promotes Ossification by Suppressing Cartilage and Enhancing Callus Mineralization During Fracture Repair in Mice

JBMR Plus, 2023
GαS, the stimulatory G protein α‐subunit that raises intracellular cAMP levels by activating adenylyl cyclase, plays a vital role in bone development, maintenance, and remodeling. Previously, using transgenic mice overexpressing GαS in osteoblasts (GS‐Tg)
Kathy K Lee, Adele Changoor, Marc D Grynpas, Jane Mitchell   +3 more
doaj   +1 more source

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Flinspach, Armin Niklas, Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Warzecha, Jörg, Wenger, Florian   +5 more
core   +1 more source

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing [PDF]

, 2020
Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing.
Brinkman, Antonia Clara Katharina, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Damerau, Alexandra, Diesing, Karoline, Gaber, Timo, Hoff, Paula, Lang, Annemarie, Ohrndorf, Sarah, Pfeiffenberger, Moritz, Pienczikowski, Justyna   +10 more
core   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Systemic treatment with telmisartan improves femur fracture healing in mice. [PDF]

PLoS ONE, 2014
Recent clinical studies indicated that angiotensin receptor blockers (ARBs) would decrease the risk of bone fractures in the elderly populations. There is little known about the role of the ARBs in the process of fracture healing.
Xiong Zhao, Jia-xing Wang, Ya-fei Feng, Zi-xiang Wu, Yang Zhang, Lei Shi, Quan-chang Tan, Ya-bo Yan, Wei Lei   +8 more
doaj   +1 more source

Outcome of Early Weight Bearing Cast for the Treatment of Jones Fracture

Journal of Bahria University Medical and Dental College, 2023
Objective: To determine the radiological and functional outcome of acute Jones fracture treated conservatively in early weight bearing cast. Study Design and Setting: This study was conducted in Orthopaedic Division Lady Reading Hospital Peshawar.
Faaiz Ali Shah, Mian Amjad Ali, Naeemullah Dawar`, Mian Javed Iqbal   +3 more
doaj   +1 more source

Mechanoregulation of bone remodeling and healing as inspiration for self-repair in materials

, 2019
The material bone has attracted the attention of material scientists due to its fracture resistance and ability to self-repair. A mechanoregulated exchange of damaged bone using newly synthesized material avoids the accumulation of fatigue damage.
Eberl, C., Fratzl, P., Weinkamer, R.
core   +1 more source

Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach [PDF]

, 2010
Recently developed atrophic non-union models are a good representation of the clinical situation in which many nonunions develop. Based on previous experimental studies with these atrophic non-union models, it was hypothesized that in order to obtain ...
A Gerisch, A Iwaki, A. Hamish R. W. Simpson, AA Reed, AAC Reed, Anita A. C. Reed, BD Boyan, C Behrens, GL Barnes, H Seeherman, Hans Van Oosterwyck, HC Brownlow, J Lienau, JD Heckman, JG Andrew, JG Andrew, JJ Tiedeman, JM Isner, Jos Vander Sloten, K Dickson, L Geris, L Geris, L Geris, L Geris, Liesbet Geris, LJ Harrison, MD Markel, ME Joyce, ME Müller, MP Bostrom, MS Pepper, Philip E. Bourne, R Dimitriou, S Jingushi, S Santavirta, SS Tseng, T Kokubu, T Niikura, T Pufe, TJ Cho   +39 more
core   +5 more sources

Temporal gene expression profiling during early-stage traumatic temporomandibular joint bony ankylosis in a sheep model

BMC Oral Health
Background Investigating the molecular biology underpinning the early-stage of traumatic temporomandibular joint (TMJ) ankylosis is crucial for discovering new ways to prevent the disease.
Tong-Mei Zhang, Kun Yang, Mai-Ning Jiao, Yan Zhao, Zhao-Yuan Xu, Guangping Zhang, Hua-Lun Wang, Su-Xia Liang, Yingbin Yan   +8 more
semanticscholar   +1 more source

AI‐Assisted Design and Evaluation of SLM‐Ti64 Implants for Enhanced Bone Regeneration

Advanced Healthcare Materials, EarlyView.
AI‐driven simulations of biological healing, combining biomechanical modeling and machine learning, enable personalized orthopedic treatments. By decoding healing patterns influenced by implants and patient‐specific factors, this approach advances fracture repair understanding, optimizes implant design, and supports precision medicine and sustainable ...
Muhammad Usama Zaheer, Muhammad Hassan Razzaq, Mehmet Fatih Aycan, Yogendra Kumar Mishra   +3 more
wiley   +1 more source