Results 51 to 60 of about 82,773 (203)

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

STUDY OF PROPORTIONAL LENGTH OF BONY SUBSTITUTION USING ORTHOTOPIC AUTOCLAVED ALLOGRAFT IN DOGS FEMUR

Assiut Veterinary Medical Journal, 2009
  Implantation of different lengths of orthotopic autoclaved allograft in the femur of dogs fixed with intramedullary pin and stainless steel wire have been performed in 11 dogs, to determine the maximum percentage of bone substitution.
KARIM AMARA, L. BOUKRAA, H. SHNAIN, M. MELLIZI   +3 more
doaj   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

Increased Osteoblast GαS Promotes Ossification by Suppressing Cartilage and Enhancing Callus Mineralization During Fracture Repair in Mice

JBMR Plus, 2023
GαS, the stimulatory G protein α‐subunit that raises intracellular cAMP levels by activating adenylyl cyclase, plays a vital role in bone development, maintenance, and remodeling. Previously, using transgenic mice overexpressing GαS in osteoblasts (GS‐Tg)
Kathy K Lee, Adele Changoor, Marc D Grynpas, Jane Mitchell   +3 more
doaj   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Micro-CT images from coronal cut aways via the central part of the 3-D reconstructions of fractured tibia at 2 (a, b) and 4 (c, d) weeks post-fracture (n = 6 per group); a, c for the OVX+vehicle group and b, d for the OVX+perindopril group.

, 2013
BC, bony callus; FL, fracture line.
Xiong Zhao (329621), Zi-xiang Wu (5652466), Yang Zhang (30734), Wei Lei (132543), Ming-xuan Gao (329624), Peng-chong Cao (329626), Ya-bo Yan (5652469), Yuan Zang (329629)   +7 more
core   +1 more source

Systemic treatment with telmisartan improves femur fracture healing in mice. [PDF]

PLoS ONE, 2014
Recent clinical studies indicated that angiotensin receptor blockers (ARBs) would decrease the risk of bone fractures in the elderly populations. There is little known about the role of the ARBs in the process of fracture healing.
Xiong Zhao, Jia-xing Wang, Ya-fei Feng, Zi-xiang Wu, Yang Zhang, Lei Shi, Quan-chang Tan, Ya-bo Yan, Wei Lei   +8 more
doaj   +1 more source

Outcome of Early Weight Bearing Cast for the Treatment of Jones Fracture

Journal of Bahria University Medical and Dental College, 2023
Objective: To determine the radiological and functional outcome of acute Jones fracture treated conservatively in early weight bearing cast. Study Design and Setting: This study was conducted in Orthopaedic Division Lady Reading Hospital Peshawar.
Faaiz Ali Shah, Mian Amjad Ali, Naeemullah Dawar`, Mian Javed Iqbal   +3 more
doaj   +1 more source

Paleopathology of a putative colossosaurian caudal vertebra (Neosauropoda: Titanosauria) from the Presidente Prudente Formation, Brazil

The Anatomical Record, EarlyView.
Abstract Studies investigating paleopathologies in sauropods remain scarce despite their relative abundance in the fossil record. In this study we report new occurrence of paleopathological features, corresponding to a neoplasm found in a middle caudal vertebra (MCT.R.2120) of an advanced titanosaur from the Presidente Prudente Formation (Bauru Basin ...
Maria Luiza Peres Bertolossi, Kamila L. N. Bandeira, Roberta Veronese do Amaral, Arthur S. Brum, Rafael C. da Silva, Valéria Gallo   +5 more
wiley   +1 more source

Modulation of fixation stiffness from flexible to stiff in a rat model of bone healing

Acta Orthopaedica, 2017
Background and purpose — Constant fixator stiffness for the duration of healing may not provide suitable mechanical conditions for all stages of bone repair.
Nicole Bartnikowski, Lutz E Claes, Lidia Koval, Vaida Glatt, Ronny Bindl, Roland Steck, Anita Ignatius, Michael A Schuetz, Devakara R Epari   +8 more
doaj   +1 more source