Results 181 to 190 of about 36,568 (244)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Feasibility and Acceptability of a Multilayered COVID-19 Mitigation Intervention for Adults With Cancer.

JAMA Netw Open
Hoerger M, Pyke N, Zimmerman DE, Srikrishna D, Garg N, Mikles B, Eastman J, Hall CJ, Peter RG, Gerhart JI.   +9 more
europepmc   +1 more source

Well-care visit attendance among children of adolescent mothers in South Africa: a theory-informed mixed-methods study. [PDF]

BMC Public Health
Wittesaele C, Mangqalaza H, Toska E, Cluver L, Weiss HA, Doyle AM.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Antenatal education for labour and postpartum pain: A scoping review of content, delivery approaches, evidence gaps, and lived experiences. [PDF]

PLoS One
Sloyan E, Leddy E, Clark C, Dufour S, Harper R, Dunford A, Elma Ö.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

PilOT-Measure: a mobile 3D depth sensing application to support accurate and efficient clinician-led home-based falls risk assessments. [PDF]

BMC Med Inform Decis Mak
Ibrahim Z, Money AG, Atwal A, Spiliotopoulou G.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

EMTReK Model for Advance Care Planning in Long-Term Care: Qualitative Findings from mySupport Study. [PDF]

Geriatrics (Basel)
Hartigan I, Buckley C, Cornally N, Brazil K, Doherty J, Walshe C, Harding AJE, Preston N, Bavelaar L, van der Steen JT, Di Giulio P, Gonella S, Kaasalainen S, Sussman T, Tétrault B, Loučka M, Vlčková K, Gonzales RA, On Behalf Of The mySupport Study Group.   +18 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source