Results 51 to 60 of about 38,277 (245)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

PENGEMBANGAN MEDIA PEMBELAJARAN BOOKLET DAN VIDEO SEBAGAI PENGUATAN KARAKTER HIDUP BERSIH DAN SEHAT

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2017
This study aims to develop learning media booklets and videos of clean and healthy life characters using the ADDIE model (1) analyze, (2) design, (3) development, (4) implementation, and (5) evaluation. The average percentage of booklet validation is 100%
Lutfin Andyana Rehusisma, Sri Endah Indriwati, Endang Suarsini   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Perbedaan Pengetahuan dan Sikap Ibu yang Mendapat Penyuluhan Menggunakan Media Aplikasi Android dan yang Mendapat Penyuluhan Menggunakan Booklet tentang Senam Hamil

Jurnal Kesehatan, 2019
The pregnancy gymnastics is useful to decrease the difficulties of normal childbirth for mothers, which means the mortalities will be decreased. The pre-survey in Negara RatuVillage, Natar District results in 6 from 10 pregnant women (60%) who don't know
Tumiur Sormin, Anita Puri
doaj   +1 more source

Pengembangan Booklet Keanekaragaman Lepidoptera Subordo Rhopalocera di Kawasan Cagar Alam Pagerwunung Darupono Kendal Sebagai Sumber Belajar Biologi pada Materi Keanekaragaman Hayati di Madrasah Aliyah

Bioeduca, 2020
Tujuan penelitian ini yaitu menjelaskan jenis Lepidoptera Subordo Rhopalocera yang ada di kawasan Cagar Alam Pagerwunung Darupono Kendal dan menjelaskan kelayakan booklet tentang Keanekaragaman Rhopalocera di kawasan Cagar Alam Pagerwunung sebagai sumber
Fitrotun Nafsiyah
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source