Results 41 to 50 of about 14,038,774 (295)

Validation of Gene Regulatory Network Inference Based on Controllability

open access: yesFrontiers in Genetics, 2013
There are two distinct issues regarding network validation: (1) Does an inferred network provide good predictions relative to experimental data? (2) Does a network inference algorithm applied within a certain network model framework yield networks that ...
Edward eDougherty, Xiaoning eQian
doaj   +1 more source

CANA: A Python Package for Quantifying Control and Canalization in Boolean Networks

open access: yesFrontiers in Physiology, 2018
Logical models offer a simple but powerful means to understand the complex dynamics of biochemical regulation, without the need to estimate kinetic parameters.
Rion B. Correia   +6 more
doaj   +1 more source

Identification of dynamic driver sets controlling phenotypical landscapes

open access: yesComputational and Structural Biotechnology Journal, 2022
Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes highly demanding because cellular decisions involve complex networks engaging in crosstalk interactions.
Silke D. Werle   +9 more
doaj   +1 more source

Deterministic and Probabilistic Boolean Control Networks and their application to Gene Regulatory Networks [PDF]

open access: yes, 2022
openThis thesis focuses on Deterministic and Probabilistic Boolean Control Networks and their application to some specific Gene Regulatory Networks. At first, some introductory materials about Boolean Logic, Left Semi-tensor Product and Probability are ...
CHECH, ALBERTO
core  

Further Results for Pinning Stabilization of Boolean Networks

open access: yes, 2021
In this article, pinning stabilization of Boolean networks is further investigated based on semi-tensor product of matrices. First, two novel algorithms are devised to obtain a globally stable Boolean network from new perspectives.
Feng, J, Lam, J, Jia, G, Meng, M
core   +1 more source

Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells

open access: yesScientific Reports, 2022
Transfection of tumor suppressor miRNAs such as miR-34a, miR-449a, and miR-16 with DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been shown to influence autophagy in cervical cancer. However, the function of miR-34a and miR-
Shantanu Gupta   +7 more
doaj   +1 more source

Are self-organizing biochemical networks emergent? [PDF]

open access: yes, 2009
Biochemical networks are often called upon to illustrate emergent properties of living systems. In this contribution, I question such emergentist claims by means of theoretical work on genetic regulatory models and random Boolean networks.
Malaterre, Christophe, C. Malaterre
core   +1 more source

Identification of periodic attractors in Boolean networks using a priori information.

open access: yesPLoS Computational Biology, 2022
Boolean networks (BNs) have been developed to describe various biological processes, which requires analysis of attractors, the long-term stable states.
Ulrike Münzner   +4 more
doaj   +1 more source

Optimal Control of Probabilistic Boolean Networks: An Information-Theoretic Approach

open access: yesIEEE Access, 2021
The primary challenge with biological sciences is to control gene regulatory networks (GRNs), thereby creating therapeutic intervention methods that alter network dynamics in the desired manner.
K. Sonam   +3 more
doaj   +1 more source

Boolean random networks: phase transition and connectivity [PDF]

open access: yes, 2023
openIn this thesis I introduce some random network models, with a particular focus on boolean random networks. After having provided the necessary theoretical background, several results related to two topics concerning boolean networks are discussed ...
SPISSO, GIOVANNI
core  

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