Results 41 to 50 of about 262,211 (238)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Balanced Boolean functions that can be evaluated so that every input bit is unlikely to be read

, 2004
A Boolean function of n bits is balanced if it takes the value 1 with probability 1/2. We exhibit a balanced Boolean function with a randomized evaluation procedure (with probability 0 of making a mistake) so that on uniformly random inputs, no input bit
Benjamini, Itai, Schramm, Oded, Wilson, David B.   +2 more
core   +1 more source

Symmetry groups of boolean functions

European Journal of Combinatorics, 2014
We prove that every abelian permutation group, but known exceptions, is the symmetry group of a boolean function. This solves the problem posed in the book by Clote and Kranakis. In fact, our result is proved for a larger class of groups, namely, for all groups contained in direct sums of regular groups.
Grech, Mariusz, Kisielewicz, Andrzej
openaire   +3 more sources

Sub‐Unit‐Cell Logic Governs Transport in TPMS Architectures

Advanced Science, EarlyView.
ABSTRACT Next‐generation energy, thermal, and chemical systems require architectures capable of highly efficient transport across multiple length scales. Triply periodic minimal surfaces (TPMS), first conceptualized in 1865, offer inherently scalable geometries with exceptional transport potential, yet mechanistic links between topology and performance
Haozhang Zhong, Yipei He, Jiaxuan Wang, Chenyi Qian, Gerd E Schröder‐Turk, Raj Das, Junye Shi, Qi Tang, Zheda Ning, Wenjue Yi, Chuanwei Li, Jiangping Chen, Zeyao Chen, Binbin Yu, Jian LU, Jianfeng Gu, Ma Qian   +16 more
wiley   +1 more source

A Nearly Optimal Lower Bound on the Approximate Degree of AC$^0$

, 2017
The approximate degree of a Boolean function $f \colon \{-1, 1\}^n \rightarrow \{-1, 1\}$ is the least degree of a real polynomial that approximates $f$ pointwise to error at most $1/3$. We introduce a generic method for increasing the approximate degree
Bun, Mark, Thaler, Justin
core   +1 more source

MGDP: Mastering a Generalized Depth Perception Model for Quadruped Locomotion

Advanced Science, EarlyView.
ABSTRACT Perception‐based Deep Reinforcement Learning (DRL) controllers demonstrate impressive performance on challenging terrains. However, existing controllers still face core limitations, struggling to achieve both terrain generality and platform transferability, and are constrained by high computational overhead and sensitivity to sensor noise.
Yinzhao Dong, Ji Ma, Yidan Lu, Jiahui Zhang, Wanyue Li, Yeke Chen, Teng Zhang, Xuechao Chen, Zhangguo Yu, Peng Lu   +9 more
wiley   +1 more source

Quantum Communications Based on Quantum Hashing [PDF]

, 2015
In this paper we consider an application of the recently proposed quantum hashing technique for computing Boolean functions in the quantum communication model. The combination of binary functions on non-binary quantum hash function is done via polynomial
Vasiliev, Alexander
core   +2 more sources

Horn functions and submodular boolean functions

Theoretical Computer Science, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ekin, Oya, Hammer, Peter L., Peled, Uri N.   +2 more
openaire   +2 more sources

Ferroelectric Devices for In‐Memory and In‐Sensor Computing

Advanced Science, EarlyView.
Inspired by biological systems, in‐memory and in‐sensor computing overcome von Neumann bottlenecks. Ferroelectric devices can mimic synaptic functions and sense stimuli like light or force, therefore are ideal for these paradigms. This review introduces the ferroelectric devices applied for in‐memory and in‐sensor computing, covering their structures ...
Hong Fang, Ronghuan Xie, Qiang Cao, Shishen Yan, Xiaolin Wang, Limei Zheng   +5 more
wiley   +1 more source