Results 111 to 120 of about 14,080,766 (337)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Ultra-Relativistic Magnetic Monopole Search with the ANITA-II Balloon-borne Radio Interferometer
, 2011 We have conducted a search for extended energy deposition trails left by ultra-relativistic magnetic monopoles interacting in Antarctic ice. The non-observation of any satisfactory candidates in the 31 days of accumulated ANITA-II flight data results in ...
A. Connolly +44 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Cosmic Ray Anomalies and Dark Matter Annihilation to Muons via a Higgs Portal Hidden Sector
, 2010 Annihilating dark matter (DM) models based on a scalar hidden sector with Higgs portal-like couplings to the Standard Model are considered as a possible explanation for recently observed cosmic ray excesses.
Kohri, Kazunori +2 more
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Power Factor Correction Using Bridgeless Boost Topology
International Journal of Advanced Engineering Research and Science, 2017 Power quality is becoming a major concern for many electrical users. The high power non linear loads (such as adjustable speed drives, arc furnace, static power converter etc) and low power loads (such as computer, fax machine etc) produce voltage fluctuations, harmonic currents and an inequality in network system which results into low power factor ...
Sachin Saini +3 more
openaire +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
BMC Cancer, 2019 Background Current recommendation for locally advanced cervical cancer includes pelvic external beam radiation therapy (EBRT) with concurrent chemotherapy followed by brachytherapy.
Caryn Wujanto +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source