Results 61 to 70 of about 285,377 (255)

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Self-rated health and health-related quality of life among cancer patients: the serial multiple mediation of anxiety and depression

BMC Psychology
Background Health-related quality of life (HRQOL) in cancer patients has attracted increasing attention, which may be associated with self-rated health (SRH), anxiety, and depression. However, limited studies have focused on the mediating role of anxiety
Shuowen Fang, Lingfeng Xu, Jingsong Liu, Xinzhou Zhang, Mimi Li, Tao Zhang, Manman Lu   +6 more
doaj   +1 more source

Internal validation strategy for high dimensional prognosis model: A simulation study and application to transcriptomic in head and neck tumors

Computational and Structural Biotechnology Journal
Background: Predictive models using high-dimensional data, such as genomics and transcriptomics, are increasingly used in oncology for time-to-event endpoints.
Antoine Dubray-Vautrin, Victor Gravrand, Grégoire Marret, Constance Lamy, Jerzy Klijanienko, Sophie Vacher, Ladidi Ahmanache, Maud Kamal, Olivier Choussy, Nicolas Servant, Célia Dupain, Christophe Le Tourneau, Jimmy Mullaert   +12 more
doaj   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Research on a hybrid model for flood probability prediction based on time convolutional network and particle swarm optimization algorithm

Scientific Reports
Accurate flood forecasting in advance is crucial for planning and implementing watershed flood prevention measures. This study developed the PSO–TCN–Bootstrap flood forecasting model for the Tailan River Basin in Xinjiang by integrating the particle ...
Qiying Yu, Chengshuai Liu, Runxi Li, Zhenlin Lu, Yungang Bai, Wenzhong Li, Lu Tian, Chen Shi, Yingying Xu, Biao Cao, Jianghui Zhang, Caihong Hu   +11 more
doaj   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Development and validation of prediction models for diabetic retinopathy in type 2 diabetes patients.

PLoS ONE
Background and objectivePrediction models enable healthcare providers to perform early risk stratification. This study aimed to develop and internally validate prediction models for 5- and 10-year risks of developing diabetic retinopathy (DR) in the ...
Shadi Naderyan Feˈli, Mohammad Hassan Emamian, Mehdi Yaseri, Hamid Riazi-Esfahani, Hassan Hashemi, Akbar Fotouhi, Kamran Yazdani   +6 more
doaj   +1 more source

Bootstrap tekniğine bağlı kümülatif toplam kontrol grafiklerinde değişim noktası analizi

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2016
Bu çalışmanın amacı değişim noktasının belirlenmesinde kullanılmak üzere “R” programlama dili için yeni geliştirilen “ChangePoint” isimli fonsiyonun tanıtılması ve bootstrap tekniğine bağlı kümülatif toplam (CUSUM) kontrol grafikleri aracılığıyla 5 Eylül-
Meral Yay, Nihan Acar Denizli, Belchin Kostov   +2 more
doaj   +1 more source

Prior Expectations Bias Confidence Judgments Through Parietal Alpha‐Band Modulation

Advanced Science, EarlyView.
ABSTRACT Humans possess the metacognitive ability to estimate the likely accuracy of their own decisions through confidence judgments. Yet, whether prior information shapes confidence and the neural mechanisms mediating such influence, remain to be determined.
Luca Tarasi, Anna Pasini, Domenico Romanazzi, Margherita Covelli, Vincenzo Romei   +4 more
wiley   +1 more source