Results 11 to 20 of about 15,214 (249)

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry [PDF]

The EMBO Journal
The evolutionarily conserved, intrinsically disordered protein Bora is critical for initiating the activation of mitotic kinases. Once phosphorylated at Ser112 by Cyclin A-Cdk1 kinase, phospho-Bora activates unphosphorylated Aurora A kinase (AURKA ...
Anaïs Pillan, Philippine Ormancey, Celia Ben Choug, Stephen Orlicky, Nicolas Tavernier, Lucie Van Hove, Batool Ossareh-Nazari, Nicolas Joly, Frank Sicheri, Thierry Lorca, Lionel Pintard   +10 more
doaj   +2 more sources

SGLT2 Inhibitors Are Associated With Suppression of the Sema3A/NRP1/Plexin-A1 Signaling Axis in Postmenopausal Women With Type 2 Diabetes: Evidence From Propensity Score-Matched Analysis. [PDF]

J Diabetes
Propensity score‐matched comparison of 23 SGLT2 inhibitor users and 23 non‐users revealed that SGLT2 inhibitor use was associated with significantly lower Neuropilin‐1 (NRP1) levels (74.25 vs. 87.61 ng/mL; p = 0.015) and a higher Sema3A/NRP1 ratio (0.14 vs.
Erarslan S, Bora BC.
europepmc   +2 more sources

Politicising Recovery: Why Early Intervention Must Move Beyond the Imperative of Functioning. [PDF]

Early Interv Psychiatry
ABSTRACT Aim To articulate the politicisation of recovery as a conceptual and clinical framework for early intervention in psychosis and to argue why the field must move beyond the imperative of functioning. Observation Early intervention for ultra‐high‐risk states and first‐episode psychosis has improved symptomatic outcomes, yet a persistent gap ...
Sibeoni J, Aquili J, Bora S, Tarabichi N, Carbonnel S, Behaghel A, Revah-Levy A.   +6 more
europepmc   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

BORA regulates cell proliferation and migration in bladder cancer

Cancer Cell International, 2020
Background Bladder cancer is having a gradually increasing incidence in China. Except for the traditional chemotherapy drugs, there are no emerging new drugs for almost 30 years in bladder cancer.
Songtao Cheng, Tianchen Peng, Xiaolu Zhu, Fenfang Zhou, Gang Wang, Lingao Ju, Yu Xiao, Xuefeng Liu, Xinghuan Wang   +8 more
doaj   +1 more source

Assessing the Risks of Vessel Icing and Aviation Hazards during Downslope Windstorms in the Russian Arctic

Atmosphere, 2021
Downslope windstorms are known sources of hazardous weather, such as severe gusty winds, rapid temperature changes, ship icing, strong turbulence and others, posing a great danger to people and infrastructure.
Anna A. Shestakova
doaj   +1 more source

Bora Flow Characteristics in a Complex Valley Environment

Remote Sensing, 2021
This paper complements the existing studies of Bora flow properties in the Vipava valley with the study of Bora turbulence in a lower region of the troposphere.
Marija Bervida, Samo Stanič, Griša Močnik, Longlong Wang, Klemen Bergant, Xiaoquan Song   +5 more
doaj   +1 more source

Influence of Novaya Zemlya Bora on Sea Waves: Satellite Measurements and Numerical Modeling

Atmosphere, 2020
This paper investigates for the first time sea waves during Novaya Zemlya bora—a downslope windstorm on the western coast of the archipelago during eastern winds—using a statistical and case-study approach.
Anna A. Shestakova, Stanislav A. Myslenkov, Alexandra M. Kuznetsova   +2 more
doaj   +1 more source

Redshifting TADF Emission With a Bora‐Triptycene Lewis Acid

Angewandte Chemie, EarlyView.
Bathochromic emission shifting of donor–acceptor and multi‐resonant TADF emitters is achieved by adduct formation with a thia‐bora‐triptycene Lewis acid. TADF properties are retained on adduct formation whilst delivering > 100 nm redshift of the emission.
Mathew J. Cross, Emily L. Hanover, Arnaud Osi, Eli Zysman‐Colman, Michael J. Ingleson   +4 more
wiley   +2 more sources

Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation

G3: Genes, Genomes, Genetics, 2017
The Drosophila melanogaster ovarian follicle cell lineage provides a powerful system for investigating how epigenetic changes contribute to differentiation.
Ming-Chia Lee, Andrew D. Skora, Allan C. Spradling   +2 more
doaj   +1 more source