The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma
Diagnostic Pathology, 2023 Aims To investigate the expression of polo-like kinase 1 protein (PLK1) and its phosphorylation level (p-PLK1) in extranodal NK/T cell lymphoma (NKTCL) and their correlation with clinical characteristics and prognosis.
Zhiqi Zhang +8 more
doaj +4 more sources
Multiple Roles of PLK1 in Mitosis and Meiosis
Cells, 2023 Cells are equipped with a diverse network of signaling and regulatory proteins that function as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell division. A key regulator of cell division is polo-like kinase 1 (PLK1),
Jaroslav Kalous, Daria Aleshkina
exaly +5 more sources
Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation
Cell Reports, 2021 Summary: Stable transmission of genetic material during cell division requires accurate chromosome segregation. PLK1 dynamics at kinetochores control establishment of correct kinetochore-microtubule attachments and subsequent silencing of the spindle ...
Binwen Sun, Xuebiao Yao, Ruijun Tian
exaly +4 more sources
Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations
PLoS Genetics, 2023 Polo-like kinase 1 (PLK1) is a serine/threonine kinase required for mitosis and cytokinesis. As cancer cells are often hypersensitive to partial PLK1 inactivation, chemical inhibitors of PLK1 have been developed and tested in clinical trials.
Karine Normandin +7 more
semanticscholar +2 more sources
PLK1 inhibition-based combination therapies for cancer management
Translational Oncology, 2021 Polo-like kinase I (PLK1), a cell cycle regulating kinase, has been shown to have oncogenic function in several cancers. Although PLK1 inhibitors, such as BI2536, BI6727 (volasertib) and NMS-1286937 (onvansertib) are generally well-tolerated with a ...
S. Su +4 more
semanticscholar +3 more sources
Characteristics and prognostic significance of polo‐like kinase‐1 (PLK1) expression in breast cancer
Histopathology, 2023 Polo‐like kinase‐1 (PLK1) plays a crucial role in cell cycle progression, and it is considered a potential therapeutic target in many cancers. Although the role of PLK1 is well established in triple‐negative breast cancer (TNBC) as an oncogene, its role ...
Nigel Mongan +2 more
exaly +2 more sources
PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models
The Journal of Clinical Investigation, 2023 Unabated activation of the NLR family pyrin domain–containing 3 (NLRP3) inflammasome is linked with the pathogenesis of various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis.
M. Baldrighi +23 more
semanticscholar +2 more sources
Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far [PDF]
Pharmaceutical Sciences, 2021 Polo-like kinase 1(Plk1) plays an important role in the inhibition of cell proliferation and which is come under the family of serine/threonine-protein kinase. Which is a highly specific target for cancer therapy.
Ramesh L. Sawant +3 more
doaj +1 more source
Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
Nature, 2023 DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle^ 1 . In interphase,
C. Gelot +13 more
semanticscholar +1 more source
Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment
Nature Communications, 2022 Immune checkpoint inhibitors (ICIs) targeting PD-L1 and PD-1 have improved survival in a subset of patients with advanced non-small cell lung cancer (NSCLC).
Moataz M. Reda +14 more
semanticscholar +1 more source