Results 41 to 50 of about 9,921 (221)
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]
, 2003 We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U. +20 more
core +1 more source
Mitotic WNT: aligning chromosomes through KIF2A
Molecular & Cellular Oncology, 2021 WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure
Anja Bufe, Sergio P. Acebrón
doaj +1 more source
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis
Nature Communications, 2021 Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is associated with dismal outcomes. RAS pathway mutations, mainly NRASG12D, define the pCMML phenotype as demonstrated by our exome sequencing, progenitor colony assays ...
Ryan M. Carr +34 more
semanticscholar +1 more source
Phosphorylation- and Polo-Box–dependent Binding of Plk1 to Bub1 Is Required for the Kinetochore Localization of Plk1 [PDF]
Molecular Biology of the Cell, 2006 Polo-like kinase 1 (Plk1) is required for the generation of the tension-sensing 3F3/2 kinetochore epitope and facilitates kinetochore localization of Mad2 and other spindle checkpoint proteins. Here, we investigate the mechanism by which Plk1 itself is recruited to kinetochores.
Wei, Qi, Zhanyun, Tang, Hongtao, Yu
openaire +2 more sources
Moonlighting at the Centrosome: RXRα Turns to Plk1 [PDF]
Developmental Cell, 2020 One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an anti-mitotic cancer therapy.
Alexsandro, Dos Santos, Sabine, Elowe
openaire +2 more sources
Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro [PDF]
, 2009 BACKGROUND: Mammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Coxon, Carmen +16 more
core +1 more source
Genes, 2022 Breast cancer is one of the most common malignant tumors in women worldwide. Early diagnosis, treatment, and prognosis of breast cancer are global challenges.
Leiming Fang +4 more
semanticscholar +1 more source
MLL5 limits PLK1 aggregation [PDF]
Journal of Cell Biology, 2016 ![Figure][1] In the absence of MLL5 (right), PLK1 aggregates in the cytoplasm and forms additional spindle poles containing pericentrin (green). Microtubules are labeled red. DNA is blue. [ Zhao et al.
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Nature Communications, 2021 Trastuzumab is the backbone of HER2-directed gastric cancer therapy, but poor patient response due to insufficient cell sensitivity and drug resistance remains a clinical challenge.
Wengui Shi +15 more
semanticscholar +1 more source
Polo-like kinase 1 promotes pulmonary hypertension
Respiratory Research, 2023 Background Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood.
Rongrong Chen +19 more
doaj +1 more source