Results 1 to 10 of about 16,178 (130)

Polo-like kinase 1 promotes pulmonary hypertension [PDF]

Respiratory Research, 2023
Background Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood.
Rongrong Chen, Hongfei Wang, Cuiting Zheng, Xiyu Zhang, Li Li, Shengwei Wang, Hongyu Chen, Jing Duan, Xian Zhou, Haiyong Peng, Jing Guo, Anchen Zhang, Feifei Li, Wang Wang, Yu Zhang, Jun Wang, Chen Wang, Yan Meng, Xinling Du, Hongbing Zhang   +19 more
doaj   +2 more sources

Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica. [PDF]

PLoS Pathogens
Fasciola sp. (liver fluke) are parasitic flatworms that impose a significant burden on the agri-food industry and human health. Immature worms can cause severe damage to the liver as they migrate towards the bile ducts, and yet there is only a single ...
Paul McCusker, Nathan G Clarke, Rebecca Armstrong, Duncan Wells, Emily Robb, Paul McVeigh, Andreas Krasky, John Harrington, Paul M Selzer, Nikki J Marks, Aaron G Maule   +10 more
doaj   +2 more sources

Identification of polo‐like kinase 1 as a therapeutic target in murine lupus [PDF]

Clinical & Translational Immunology, 2022
Introduction The signalling cascades that contribute to lupus pathogenesis are incompletely understood. We address this by using an unbiased activity‐based kinome screen of murine lupus.
Yaxi Li, Hongting Wang, Zijing Zhang, Chenling Tang, Xinjin Zhou, Chandra Mohan, Tianfu Wu   +6 more
doaj   +2 more sources

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold [PDF]

Advanced Science
Cytoskeleton‐organizing organelles often function while under mechanical load. The outer layer of centrosomes, called pericentriolar material (PCM), nucleates microtubules that move chromosomes during mitosis.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
doaj   +2 more sources

Polo-like Kinase 1 Expression as a Biomarker in Colorectal Cancer: A Retrospective Two-Center Study [PDF]

Biomedicines
Background/Objectives: Early-onset colorectal cancer (EOCRC) is more frequently characterized by poorly differentiated, aggressive tumors, often diagnosed at advanced stages, and associated with worse prognoses.
Lana Jajac Brucic, Vesna Bisof, Majana Soce, Marko Skelin, Ivan Krecak, Andjela Nadinic, Branka Vrbicic, Zivana Puljiz, Suzana Hancic, Slavko Gasparov   +9 more
doaj   +2 more sources

Polo-like Kinase 1 Activation Regulates Angiotensin II-Induced Contraction in Pudendal and Small Mesenteric Arteries from Mice [PDF]

Cells
Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase expressed in smooth muscle cells (SMCs), with emerging roles in regulating contraction. We hypothesize that PLK1 contributes to smooth muscle contractility in pudendal arteries (PA), small ...
Raiana Anjos Moraes, Olufunke O. Arishe, James Pratt, Stephanie Wilczynski, Rinaldo Rodrigues dos Passos, Diana L. Silva-Velasco, Tiago Tomazini Gonçalves, Tianxin Zhang, Darizy Flavia Silva, R. Clinton Webb, Fernanda Priviero   +10 more
doaj   +2 more sources

Targeting Oral Squamous Cell Carcinoma with Combined Polo-Like-Kinase-1 Inhibitors and γ-Radiation Therapy [PDF]

Biomedicines
Polo-like-kinase-1 (PLK-1) is a serine/threonine kinase that regulates the cell cycle and acts as an oncogene in multiple cancers, including oral squamous cell carcinoma (OSCC).
Subhanwita Sarkar, Ayan Chanda, Rutvij A. Khanolkar, Meghan Lambie, Laurie Ailles, Scott V. Bratman, Aru Narendran, Pinaki Bose   +7 more
doaj   +2 more sources

Pan-cancer analysis of polo-like kinase family genes reveals polo-like kinase 1 as a novel oncogene in kidney renal papillary cell carcinoma [PDF]

Heliyon
Background: Polo-like kinases (PLKs) are a kinase class of serine/threonine with five members that play crucial roles in cell cycle regulation. However, their biological functions, regulation, and expression remain unclear.
Guo Zhao, Yuning Wang, Jiawei Zhou, Peiwen Ma, Shuhang Wang, Ning Li   +5 more
doaj   +2 more sources

Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far [PDF]

Pharmaceutical Sciences, 2021
Polo-like kinase 1(Plk1) plays an important role in the inhibition of cell proliferation and which is come under the family of serine/threonine-protein kinase. Which is a highly specific target for cancer therapy.
Ramesh L. Sawant, Jyoti B. Wadekar, Rushikesh D. Ukirde, Ganesh D. Barkade   +3 more
doaj   +1 more source

Polo-like kinase 1 as a promising diagnostic biomarker and potential therapeutic target for hepatocellular carcinoma

Tumor Biology, 2020
Hepatocellular carcinoma is a major cause of cancer mortality worldwide. The outcome of hepatocellular carcinoma depends mainly on its early diagnosis. To date, the performance of traditional biomarkers is unsatisfactory.
Eman H. Yousef, Mohamed E El-Mesery, Maha R Habeeb, Laila A Eissa   +3 more
doaj   +1 more source