Results 1 to 10 of about 42,681 (176)

Polo-like kinase 1 promotes pulmonary hypertension. [PDF]

Respir Res, 2023
Background Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood.
Chen R, Wang H, Zheng C, Zhang X, Li L, Wang S, Chen H, Duan J, Zhou X, Peng H, Guo J, Zhang A, Li F, Wang W, Zhang Y, Wang J, Wang C, Meng Y, Du X, Zhang H.   +19 more
europepmc   +5 more sources

Monoclonal Antibodies Accessing the Cytosol of Living Cells and Binding to Polo-Like Kinase 1 Interdomain Linker Affect Mitotic Behavior. [PDF]

Chembiochem
Monoclonal antibodies targeting the interdomain region of polo‐like kinase 1 (PLK1) were delivered into living HeLa cells by electroporation to directly modulate mitotic progression. This intracellular antibody approach provides a new tool to probe PLK1 function and highlights the potential of antibodies to regulate key mitotic regulators inside cells.
Steyer C, Amé JC, Donzeau M, Shen K, Chiper M, Zuber G.   +5 more
europepmc   +2 more sources

Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients. [PDF]

Oncol Res, 2023
Shen J, Zhang W, Jin Q, Gong F, Zhang H, Xu H, Li J, Yao H, Jiang X, Yang Y, Hong L, Mei J, Song Y, Zhou S.   +13 more
europepmc   +1 more source

Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis. [PDF]

Oncol Res, 2023
Zhang P, Zhang X, Zhu Y, Cui Y, Xu J, Zhang W.   +5 more
europepmc   +1 more source

The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors. [PDF]

Cells, 2023
Moore XTR, Gheghiani L, Fu Z.
europepmc   +1 more source

Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition. [PDF]

Proc Natl Acad Sci U S A, 2023
Park JE, Kirsch K, Lee H, Oliva P, Ahn JI, Ravishankar H, Zeng Y, Fox SD, Kirby SA, Badhwar P, Andresson T, Jacobson KA, Lee KS.   +12 more
europepmc   +1 more source

Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos. [PDF]

Sci Adv, 2023
Nkombo Nkoula S, Velez-Aguilera G, Ossareh-Nazari B, Van Hove L, Ayuso C, Legros V, Chevreux G, Thomas L, Seydoux G, Askjaer P, Pintard L.   +10 more
europepmc   +1 more source

Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica. [PDF]

PLoS Pathog
McCusker P, Clarke NG, Armstrong R, Wells D, Robb E, McVeigh P, Krasky A, Harrington J, Selzer PM, Marks NJ, Maule AG.   +10 more
europepmc   +1 more source

Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer. [PDF]

Life Sci Alliance, 2023
El-Khobar KE, Tay E, Diefenbach E, Gloss BS, George J, Douglas MW.   +5 more
europepmc   +1 more source

Nitidine chloride suppresses polo-like kinase 1 via MYCN-associated transcriptional regulation in colorectal cancer: a multi-omics and spatial transcriptomics study. [PDF]

Front Oncol
Huang XJ, Mo LH, Wu KJ, He RQ, Li H, Chen G, Liu LM.   +6 more
europepmc   +1 more source