Results 31 to 40 of about 42,681 (176)

Polo-like kinase 1 (PLK1) signaling in cancer and beyond

Biochemical Pharmacology, 2021
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle. PLK1-mediated phosphorylation of specific substrates controls cell entry into mitosis, centrosome maturation, spindle assembly, sister chromatid cohesion and cytokinesis.
Styliani Iliaki, Rudi Beyaert, Inna S. Afonina   +2 more
openaire   +3 more sources

Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells [PDF]

, 2013
This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Caron, HN, Allen, M. (Matthew), Hartsink-Segers, Stefanie A., Horstmann, Martin, Horstmann, M.A. (Martin), Boer, M.L. (Monique) den, Allen, Matthew, Horstmann, M, Clifford, Steven C., Caron, Huib N., Exalto, C. (Carla), Caron, H.N. (Huib), Clifford, SC, Williamson, Daniel, den Boer, Monique L., Pieters, Rob, Hartsink-Segers, S.A. (S.), Williamson, D, Clifford, S.C. (Steven), den Boer, Monique, Exalto, Carla, Allen, M, Segers, Stefanie, Williamson, D. (Daniel), Pieters, R. (Rob)   +24 more
core   +1 more source

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

, 2011
High attrition rates of novel anti-cancer drugs highlight the need for improved models to predict toxicity. Although polo-like kinase 1 (Plk1) inhibitors are attractive candidates for drug development, the role of Plk1 in primary cells remains widely ...
Kappel, Sven, Eckhard Wolf, Kreft, B., Martin Bergmann, Martin Klingenspor, Prinz, Florian, Kurunci-Csacsko, Elisabeth, Nicole Sänger, Knecht, R., Jost Seibler, Thure Adler, Florian Prinz, Strebhardt, K., Hrabě de Angelis, M., Busch, D.H., Monika Raab, Sanhaji, Mourad, Yves Matthess, Martin Hrabě de Angelis, Bergmann, M., Adler, Thure, Seibler, Jost, Rathkolb, Birgit, Irene Esposito, Dirk H. Busch, Rathkolb, B., Rozman, J., Rozman, Jan, Esposito, Irene, Yuan, J., Andrea Krämer, Fuchs, H., Calzada-Wack, Julia, Jan Rozman, Rainald Knecht, Esposito, I., Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Knecht, Rainald, Valérie Gailus-Durner, Wolf, E., Prinz, F., Sänger, Nicole, Krämer, A., Calzada-Wack, J., Gailus-Durner, V., Kappel, S., Helmut Fuchs, Kurunci-Csacsko, E., Klingenspor, Martin, Yuan, Juping, Matthess, Yves, Busch, Dirk H., Klaus Strebhardt, Strebhardt, Klaus, Juping Yuan, Kreft, Bertolt, Julia Calzada-Wack, Sven Kappel, Krämer, Andrea, Klingenspor, M., Matthess, Y., Bergmann, Martin, Birgit Rathkolb, Adler, T., Elisabeth Kurunci-Csacsko, Sänger, N., Raab, Monika, Bertolt Kreft, Fuchs, Helmut, Wolf, Eckhard, Mourad Sanhaji, Raab, M., Sanhaji, M., Seibler, J.   +74 more
core   +1 more source

Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]

, 2012
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe, Fabbro, Doriano, Doriano Fabbro, Huwiler Andrea, Zangemeister-Wittke Uwe, Huwiler, Andrea, Uwe Zangemeister-Wittke, Kotelevets Nataliya, Nataliya Kotelevets (156133), Kotelevets, Nataliya, Nataliya Kotelevets, Andrea Huwiler, Doriano Fabbro (156139), Andrea Huwiler (156145), Uwe Zangemeister-Wittke (156150), Fabbro Doriano   +15 more
core   +1 more source

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution [PDF]

, 2014
Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR ...
DeMayo, Fransesco J., San-Pin Wu, David D Moore, Moore, David D, Whitby, Richard J., Martin Wagner, Moore, David D., Peter J Stambrook, Whitby, Richard J, Sifers, Richard N, Ming-Jer Tsai, Francesco J DeMayo, Wu, San-pin, Mamrosh, Jennifer L, Jennifer L Mamrosh, Lee, Jae Man, Sifers, Richard N., Richard N Sifers, Richard J Whitby, Stambrook, Peter J, Stambrook, Peter J., Jae Man Lee, Wagner, Martin, Tsai, Ming-jer, Lee, Jae M., DeMayo, Francesco J, Mamrosh, Jennifer L.   +26 more
core   +1 more source

Polo-Like Kinase 1: Target and Regulator of Transcriptional Control [PDF]

Cell Cycle, 2006
Deregulated cell cycle control is a hallmark of cancer cells. Developmental or other mitogenic stimuli activate the proliferation of normal cells in response to the requirements of growing tissues. In contrast, cancer cells liberate from proliferative restrictions exerted by anti-proliferative signals arising from the stroma and by endogenous genetic ...
Bernd T, Martin, Klaus, Strebhardt
openaire   +2 more sources

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Tumor inhibition by genomically integrated inducible RNAi-cassettes

, 2006
RNA interference (RNAi) has emerged as a powerful tool to induce loss-of-function phenotypes by post-transcriptional silencing of gene expression. In this study we wondered whether inducible RNAi-cassettes integrated into cellular DNA possess the power ...
Kappel, Sven, Zimmer, Brigitte, Brigitte Zimmer, Manfred Kaufmann, Yves Matthess, Matthess, Yves, Klaus Strebhardt, Strebhardt, Klaus, Kaufmann, Manfred   +8 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source