Results 31 to 40 of about 33,833,464 (200)

Linear Regression QSAR Models for Polo-Like Kinase-1 Inhibitors

Cells, 2018
A structurally diverse dataset of 530 polo-like kinase-1 (PLK1) inhibitors is compiled from the ChEMBL database and studied by means of a conformation-independent quantitative structure-activity relationship (QSAR) approach.
Pablo R. Duchowicz
doaj   +1 more source

Modulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention [PDF]

Pharmaceutical Research, 2010
Naturally occurring agents have always been appreciated for their medicinal value for both their chemopreventive and therapeutic effects against cancer. In fact, the majority of the drugs we use today, including the anti-cancer agents, were originally derived from natural compounds, either in their native form or modified to enhance their ...
Travis L, Schmit, Mark C, Ledesma, Nihal, Ahmad   +2 more
openaire   +2 more sources

PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma

Endocrine Connections, 2023
Adrenocortical carcinoma (ACC) is an aggressive malignancy with limited treatment options. Polo-like kinase 1 (PLK1) is a promising drug target; PLK1 inhibitors (PLK1i) have been investigated in solid cancers and are more effective in TP53-mutated cases.
Emily Warmington, Gabrielle Smith, Vasileios Chortis, Raimunde Liang, Juliane Lippert, Sonja Steinhauer, Laura-Sophie Landwehr, Constanze Hantel, Katja Kiseljak-Vassiliades, Margaret E Wierman, Barbara Altieri, Paul A Foster, Cristina L Ronchi   +12 more
doaj   +1 more source

Polo-like kinase 1 (PLK1) signaling in cancer and beyond

Biochemical Pharmacology, 2021
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle. PLK1-mediated phosphorylation of specific substrates controls cell entry into mitosis, centrosome maturation, spindle assembly, sister chromatid cohesion and cytokinesis.
Styliani Iliaki, Rudi Beyaert, Inna S. Afonina   +2 more
openaire   +3 more sources

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells [PDF]

, 2011
High attrition rates of novel anti-cancer drugs highlight the need for improved models to predict toxicity. Although polo-like kinase 1 (Plk1) inhibitors are attractive candidates for drug development, the role of Plk1 in primary cells remains widely ...
Kappel, Sven, Eckhard Wolf, Kreft, B., Martin Bergmann, Martin Klingenspor, Prinz, Florian, Kurunci-Csacsko, Elisabeth, Nicole Sänger, Knecht, R., Jost Seibler, Thure Adler, Florian Prinz, Strebhardt, K., Hrabě de Angelis, M., Busch, D.H., Monika Raab, Sanhaji, Mourad, Yves Matthess, Martin Hrabě de Angelis, Bergmann, M., Adler, Thure, Seibler, Jost, Rathkolb, Birgit, Irene Esposito, Dirk H. Busch, Rathkolb, B., Rozman, J., Rozman, Jan, Esposito, Irene, Yuan, J., Andrea Krämer, Fuchs, H., Calzada-Wack, Julia, Jan Rozman, Rainald Knecht, Esposito, I., Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Knecht, Rainald, Valérie Gailus-Durner, Wolf, E., Prinz, F., Sänger, Nicole, Krämer, A., Calzada-Wack, J., Gailus-Durner, V., Kappel, S., Helmut Fuchs, Kurunci-Csacsko, E., Klingenspor, Martin, Yuan, Juping, Matthess, Yves, Busch, Dirk H., Klaus Strebhardt, Strebhardt, Klaus, Juping Yuan, Kreft, Bertolt, Julia Calzada-Wack, Sven Kappel, Krämer, Andrea, Klingenspor, M., Matthess, Y., Bergmann, Martin, Birgit Rathkolb, Adler, T., Elisabeth Kurunci-Csacsko, Sänger, N., Raab, Monika, Bertolt Kreft, Fuchs, Helmut, Wolf, Eckhard, Mourad Sanhaji, Raab, M., Sanhaji, M., Seibler, J.   +74 more
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The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. [PDF]

PLoS Biology, 2010
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis.
Conrad von Schubert, Gongda Xue, Jacqueline Schmuckli-Maurer, Kerry L Woods, Erich A Nigg, Dirk A E Dobbelaere   +5 more
doaj   +1 more source

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]

, 2015
Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Timm Maier, Gabryjonczyk, Anna-Maria, Hiller, Sebastian, Imseng, Stefan, Böhm, Raphael, Maier, Timm, Christian Arquint, Raphael Böhm, Sebastian Hiller, Anna-Maria Gabryjonczyk, Arquint, Christian, Stefan Imseng, Nigg, Erich A., Evelyn Sauer, Erich A Nigg, Sauer, Evelyn   +15 more
core   +1 more source

On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]

, 2015
Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core   +1 more source

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Haematologica, 2017
Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine kinase anexelekto is critical for FMS-like tyrosine kinase 3 signaling and participates in FMS ...
Peter P. Ruvolo, Huaxian Ma, Vivian R. Ruvolo, Xiaorui Zhang, Hong Mu, Wendy Schober, Ivonne Hernandez, Miguel Gallardo, Joseph D. Khoury, Jorge Cortes, Michael Andreeff, Sean M. Post   +11 more
doaj   +1 more source

Tumor inhibition by genomically integrated inducible RNAi-cassettes [PDF]

, 2006
RNA interference (RNAi) has emerged as a powerful tool to induce loss-of-function phenotypes by post-transcriptional silencing of gene expression. In this study we wondered whether inducible RNAi-cassettes integrated into cellular DNA possess the power ...
Kappel, Sven, Zimmer, Brigitte, Brigitte Zimmer, Manfred Kaufmann, Yves Matthess, Matthess, Yves, Klaus Strebhardt, Strebhardt, Klaus, Kaufmann, Manfred   +8 more
core   +1 more source