Results 51 to 60 of about 42,681 (176)

SBE13, a newly identified inhibitor of inactive polo-like kinase 1

, 2010
Poster presentation at 5th German Conference on Cheminformatics: 23. CIC-Workshop Goslar, Germany. 8-10 November 2009 Protein kinases are important targets for drug development.
Ewgenij Proschak, Keppner Sarah, Keppner, Sarah, Proschak, Ewgenij, Spänkuch B, Sarah Keppner, Spänkuch-Schmitt, Birgit, Schneider, Gisbert (Prof. Dr.), Gisbert Schneider, B Spänkuch, Proschak Ewgenij, Schneider Gisbert   +11 more
core   +1 more source

The Role of Polo-like Kinase 1 in Carcinogenesis: Cause or Consequence? [PDF]

Cancer Research, 2013
Abstract Polo-like kinase 1 (Plk1) is a well-established mitotic regulator with a diverse range of biologic functions continually being identified throughout the cell cycle. Preclinical evidence suggests that the molecular targeting of Plk1 could be an effective therapeutic strategy in a wide range of cancers; however, that success has ...
Brian D, Cholewa, Xiaoqi, Liu, Nihal, Ahmad   +2 more
openaire   +2 more sources

Oclacitinib for Controlling Pruritus and Associated Skin Lesions in 16 Horses With Allergic Dermatitis

Veterinary Dermatology, EarlyView.
Background: Oclacitinib is a Janus kinase inhibitor approved for the treatment of pruritus associated with allergic dermatitis in dogs and may be effective in horses. Objectives: To evaluate the efficacy of oclacitinib in reducing pruritus and skin lesions in horses with allergic dermatitis.
Nuttawut Nuchprayoon, Photchanun Maneephan, Natcha Tovanakasame, Chalidaporn Kampang, Pusprapa Jandee, Panpanga Sangsuriya, Maturawan Tunhikorn   +6 more
wiley   +1 more source

Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres [PDF]

Cell, 2014
To ensure the stable transmission of the genome during vertebrate cell division, the mitotic spindle must attach to a single locus on each chromosome, termed the centromere. The fundamental requirement for faithful centromere inheritance is the controlled deposition of the centromere-specifying histone, CENP-A.
McKinley, Kara Lavidge, Cheeseman, Iain M   +1 more
openaire   +4 more sources

Identification of Distinct Interacting Proteins of Giardia lamblia Centrins Using Yeast Two‐Hybrid Assays

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Giardia lamblia, a protozoan parasite that causes diarrhea in humans, contains two centrins implicated in cellular morphology and cell division. To identify proteins interacting with each G. lamblia centrin (GlCent), we performed a yeast two‐hybrid assay.
Mee Young Shin, Juri Kim, Soon‐Jung Park   +2 more
wiley   +1 more source

SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS [PDF]

, 2020
Targeted therapies are crucial for personalizing cancer treatment, but tumour heterogeneity presents a challenge in the identification of effective targets.
Cunningham, Chelsea E
core  

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Polo-like Kinase 1 as a Target for Anti-tumor Therapy

Klinicka onkologie, 2015
Individual proteins from polo-like kinase (Plk) family fulfil different but critical functions in regulating cell cycle and coordinate cell response to DNA  damage. The most studied one from this five  member family is Plk1. It is a serine/ threonine kinase that plays a pivotal role in many aspects of mitosis and its deregulation is common in various ...
I, Procházková, B, Vojtěšek
openaire   +2 more sources

Roles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles [PDF]

Current Biology, 2004
The stable association of chromosomes with both poles of the mitotic spindle (biorientation) depends on spindle pulling forces. These forces create tension across sister kinetochores and are thought to stabilize microtubule-kinetochore interactions and to silence the spindle checkpoint.
Sumara, Izabela, Giménez-Abián, Juan F, Gerlich, Daniel, Hirota, Toru, Kraft, Claudine, de la Torre, Consuelo, Ellenberg, Jan, Peters, Jan-Michael   +7 more
openaire   +3 more sources

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status

International Journal of Cancer, Volume 158, Issue 12, Page 3268-3278, 15 June 2026.
What's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Klaus W. Fagerstedt, Sami Kilpinen, Johanna Arola, Benjamin Z. Sundqvist, Tom Böhling, Leif C. Andersson, Harri Sihto   +6 more
wiley   +1 more source