Results 61 to 70 of about 33,833,464 (200)
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
The Role of Polo-like Kinase 1 in Carcinogenesis: Cause or Consequence? [PDF]
Cancer Research, 2013 Abstract Polo-like kinase 1 (Plk1) is a well-established mitotic regulator with a diverse range of biologic functions continually being identified throughout the cell cycle. Preclinical evidence suggests that the molecular targeting of Plk1 could be an effective therapeutic strategy in a wide range of cancers; however, that success has ...
Brian D, Cholewa +2 more
openaire +2 more sources
High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena +7 more
wiley +1 more source
Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres [PDF]
Cell, 2014 To ensure the stable transmission of the genome during vertebrate cell division, the mitotic spindle must attach to a single locus on each chromosome, termed the centromere. The fundamental requirement for faithful centromere inheritance is the controlled deposition of the centromere-specifying histone, CENP-A.
McKinley, Kara Lavidge +1 more
openaire +4 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Identification of Rictor as a Novel Substrate of Polo-like kinase 1 [PDF]
Cell Cycle, 2015 Plk1 has been essentially described as a critical regulator of many mitotic events. However, increasing evidence supports the notion that its molecular functions are not restricted to the cell cycle. In particular, recent reports suggest the existence of a molecular and functional link between Plk1 and the mammalian target of rapamycin (mTOR) pathway ...
Tian, Shao, Xiaoqi, Liu
openaire +2 more sources
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
The function of mammalian Polo-like kinase 1 in microtubule nucleation [PDF]
Proceedings of the National Academy of Sciences, 2011 Mitotic spindle, the structure essential for equal partitioning of the chromosomes into daughter cells, is of pivotal importance for the maintenance of genomic stability during cell division (1). Microtubules (MTs) that constitute the mitotic spindle are polymers of α- and β-tubulin dimers. Generation of MT starts with a process called MT nucleation in
Dazhong, Xu, Wei, Dai
openaire +2 more sources
Enhanced polo-like kinase 1 expression in myelodysplastic syndromes
BLOOD RESEARCH, 2019 Cancer is characterized by uncontrolled cellular proliferation, and Polo-like kinase 1 (PLK1), a key regulator of the cell cycle, is overexpressed in many cancers, including acute leukemia and lymphoma. However, the dynamics of PLK1 transcription in myelodysplastic syndromes (MDS) are unknown.
Min, Kyoung Il +5 more
openaire +3 more sources
Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1
The FEBS Journal, EarlyView.In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández +4 more
wiley +1 more source