Results 61 to 70 of about 42,681 (176)
Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]
, 2012 Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core +1 more source
Targeting polo-like kinase 1 in acute myeloid leukemia [PDF]
Therapeutic Advances in Hematology, 2015 Polo-like kinase 1 (Plk1) plays a number of important roles in the passage of cells through mitosis. It is expressed at high levels in a variety of malignancies, including acute myeloid leukemia (AML). Inhibition of Plk1 results in cell cycle arrest and apoptosis, and has anti-tumor effects in pre-clinical models.
openaire +2 more sources
p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors [PDF]
Cell Cycle, 2012 Polo-like kinase 1 (Plk1) is elementary for cell proliferation and its deregulation is involved in tumorigenesis. Plk1 has been established as one of the most attractive targets for molecular cancer therapy. In fact, multiple small molecule inhibitors targeting either the kinase domain or the Polo-box binding domain (PBD) of Plk1 have been identified ...
Sanhaji, M. +5 more
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From Food Waste to Valorized Nanomaterials: Sustainable Green Synthesis and Biomedical Applications
ChemFoodChem, Volume 2, Issue 2, June 2026.Food waste‐derived biomolecules act as natural reducing and stabilizing agents for the green synthesis of functional NPs with applications in antimicrobial systems, food packaging, biomedical technologies, and environmental remediation. ABSTRACT Food waste is a global issue, with billions of tons discarded and unutilized annually, causing economic ...
Siddhraj Rajput +8 more
wiley +1 more source
On the regulation of chromosome segregation in human cells : implications of Bub1 Kinase inhibition during cell division [PDF]
, 2015 The maintenance of correct chromosome number (euploidy) during cell division is essential for health. Loss of euploidy is observed in most cancers and is linked to tumorigenesis.
Baron, Anna
core +1 more source
Polo-Like Kinase 1 is a Therapeutic Target in High-Risk Neuroblastoma [PDF]
Clinical Cancer Research, 2011 Abstract Purpose: High-risk neuroblastoma remains a therapeutic challenge for pediatric oncologists. The Polo-like kinase 1 (PLK1) is highly expressed in many human cancers and is a target of the novel small-molecule inhibitor BI 2536, which has shown promising anticancer activity in adult malignancies.
Ackermann, Sandra +8 more
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Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) of the parent drug and metabolite(s) in the human body and are normally conducted in healthy volunteers ...
Begoña de las Heras +9 more
wiley +1 more source
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy [PDF]
, 2007 Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor.
Kellems, Rodney E. +19 more
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Molecular Microbiology, Volume 125, Issue 6, Page 475-492, June 2026.Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark +11 more
wiley +1 more source
Cancer, Volume 132, Issue 10, 15 May 2026.Momelotinib demonstrated robust real‐world activity after ruxolitinib failure, with clinically meaningful improvements in spleen (≥50% spleen length reduction, 30.0%), symptoms (≥50% total symptoms score reduction, 39.2%), and anemia (major response, 35.7%) at 6 months.
Francesca Palandri +41 more
wiley +1 more source