Results 81 to 90 of about 42,681 (176)

The family of polo-like kinases

, 1996
Here we discuss members of a new family of serine/threonine protein kinases with a likely role in cell cycle control. These kinases are referred to as polo-like kinases, after the prototypic founding member of the family, the polo gene product of ...
Erich A. Nigg, Lynne D. Berry, Nigg, E. A., Roy M. Golsteyn, Golsteyn, R. M., Heidi A. Lane, Kirsten E. Mundt, Arnaud, L., Mundt, Kirsten E., Lionel Arnaud, Mundt, K. E., Golsteyn, Roy M., Lane, H. A., Nigg, Erich A., Arnaud, Lionel Jean-Claude, Lane, Heidi A.   +15 more
core   +1 more source

Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication [PDF]

, 2012
Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process.
Liu Xiaoqi, X. SHAWN Liu, Liu X Shawn, Bing Song, Song Bing, Xiaoqi Liu, Bing Song   +6 more
core   +1 more source

Inhibition of polo-like kinase 1 by blocking Polo-box domain-dependent protein-protein interactions

, 2008
SummaryThe serine/threonine kinase Polo-like kinase 1 (Plk1) is overexpressed in many types of human cancers, and has been implicated as an adverse prognostic marker for cancer patients.
Yuan, Juping, Berg, Thorsten, Reindl, Wolfgang, Krämer, Andrea, Yuan, J. P., Strebhardt, Klaus, Krämer, A., Reindl, W. G., Berg, T., Strebhardt, K.   +9 more
core   +1 more source

A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening

, 2019
Polo-like kinase 1 (PLK1), a member of the Polo-like kinase family, plays an important regulatory role in mitosis and cell cycle progression. PLK1 overexpression is correlated with tumourigenesis and poor prognosis in cancer patients.
Angela Berg, Thomas Efferth, Madeleine Böckers, Sara Abdelfatah   +3 more
core   +1 more source

RETRACTION: Polo‐Like Kinase 4 Correlates With Greater Tumor Size, Lymph Node Metastasis, and Confers Poor Survival in Non‐Small Cell Lung Cancer

Journal of Clinical Laboratory Analysis, Volume 40, Issue 10, May 2026.
RETRACTION: Q. Zhou, G. Fan, Y. Dong, “Polo‐Like Kinase 4 Correlates With Greater Tumor Size, Lymph Node Metastasis, and Confers Poor Survival in Non‐Small Cell Lung Cancer,” Journal of Clinical and Laboratory Analysis 34, no. 4 (2019): e23152, https://doi.org/10.1002/jcla.23152.
wiley   +1 more source

Fisher’s test of association between tumour periphery (TP) polo-like kinase 1 (PLK1) scores and clinicopathological variables.

, 2015
Fisher’s test of association between tumour periphery (TP) polo-like kinase 1 (PLK1) scores and clinicopathological variables.
J. Descallar (750038), J-S. Shin (750042), W. Chua (750039), C. S. Lee (750043), P. de Souza (750041), I. U. Dissanayake (750037), W. Ng (750040), T. G. Tut (750035), S. H. S. Lim (750036)   +8 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

The polo-like kinase 1 regulates CDC25B-dependent mitosis entry

, 2009
Activation of cyclin-dependent kinase complexes (CDK) at key cell cycle transitions is dependent on their dephosphorylation by CDC25 dual-specificity phosphatases (CDC25A, B and C in human).
Bouché, Jean-Pierre, Lobjois, Valerie, Jullien, Denis, Ducommun, Bernard   +3 more
core   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer

, 2019
Within triple negative breast cancer, several molecular subtypes have been identified, underlying the heterogeneity of such an aggressive disease.
Liu, Y, Carolyn Britten (3913825), Giordano, Antonio, Britten, Carolyn, Erlander, M, Yeh, E, Antonio Giordano (55096), Armeson, K, Maya Ridinger (7907765), Reuben, J, Stephen Ethier (3587654), Kappler, Christiana, Ridinger, Maya, Yeonhee Park (7907762), Erlander, Mark, Yueying Liu (1635625), Giordano, Antonio|, James Reuben (218188), Reuben, James, Britten, C, Park, Y, Mark Erlander (3400253), Christiana Kappler (7907768), Ethier, S, Kappler, C, Kent Armeson (6731102), Park, Yeonhee, Yeh, Elizabeth, Ethier, Stephen, Elizabeth Yeh (6731093), Liu, Yueying, Ridinger, M, Armeson, Kent, Giordano, A   +33 more
core   +1 more source