Results 81 to 90 of about 33,833,464 (200)
MedComm, Volume 7, Issue 10, October 2026.Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna +3 more
wiley +1 more source
Chinese Journal of Cancer, 2016 The KRAS gene is frequently mutated in multiple cancer types, but it fell off the drug discovery radar for many years because of its inherent “undruggable” structure and undefined biological properties.
Xiufeng Pang, Mingyao Liu
doaj +1 more source
Posttranslational Modifications of p62/SQSTM1 in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang +8 more
wiley +1 more source
Veterinary Dermatology, Volume 37, Issue 5, Page 672-680, October 2026.Background: Oclacitinib is a Janus kinase inhibitor approved for the treatment of pruritus associated with allergic dermatitis in dogs and may be effective in horses. Objectives: To evaluate the efficacy of oclacitinib in reducing pruritus and skin lesions in horses with allergic dermatitis.
Maturawan Tunhikorn +6 more
wiley +1 more source
Roles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles [PDF]
Current Biology, 2004 The stable association of chromosomes with both poles of the mitotic spindle (biorientation) depends on spindle pulling forces. These forces create tension across sister kinetochores and are thought to stabilize microtubule-kinetochore interactions and to silence the spindle checkpoint.
Sumara, Izabela +7 more
openaire +3 more sources
BMEMat, Volume 4, Issue 3, September 2026.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source
Marcadores moleculares e morfológicos da citocinese em Trypanosoma rangeli [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2013.O Trypanosoma rangeli é um protozoário que, embora estreitamente relacionado ao ...
Prestes, Elisa Beatriz
core
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Yixian Zhu +4 more
wiley +1 more source
Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution [PDF]
, 2014 Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR ...
DeMayo, Fransesco J. +26 more
core +1 more source
Essential role for a novel population of binucleated mammary epithelial cells in lactation
Nature Communications, 2016 The main function of the mammary gland is to produce milk to sustain offspring. Here, the authors show that secretory alveolar cells in the lactating gland in several species are binucleated, which increases milk production, and that binucleation is ...
Anne C. Rios +7 more
doaj +1 more source