Results 91 to 100 of about 42,681 (176)
A New Class of Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1
, 2016 Recent progress in the development of peptide-derived Polo-like kinase (Plk1) polo-box domain (PBD) inhibitors has led to the synthesis of multiple peptide ligands with high binding affinity and selectivity.
Nam-Hyung Kim (293371) +13 more
core +1 more source
Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1
, 2013 The polo-box domain (PBD) of polo-like kinase 1 (Plk1) is essentially required for the function of Plk1 in cell proliferation. The availability of the phosphopeptide-binding pocket on PBD provides a unique opportunity to develop novel protein-protein ...
K S Lee +13 more
core +1 more source
Polo-like Kinase 1 Inhibition in KRAS-Mutated Metastatic Colorectal Cancer
Summary: Inhibition of Polo-like kinase 1 (Plk1) is a promising new target and therapeutic strategy in metastatic colorectal cancer, especially those with KRAS mutations.
Justin Stebbing (181883) +1 more
core
, 2015 Abbreviations: CI = confidence intervals, PLK1 = polo-like kinase 1, TIL = tumour-infiltrating lymphocytes, TP = tumour periphery* denotes interactionUnivariate analyses and multivariate model of tumour periphery (TP) polo-like kinase 1 (PLK1) scores ...
J. Descallar (750038) +8 more
core +1 more source
This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Caron HN +8 more
core
, 2019 Faithful chromosome segregation cannot be achieved without correctly aligning each chromosome pair, a process referred to as chromosome biorientation.
Owen Addis (4464076)
core +1 more source