Results 41 to 50 of about 33,833,464 (200)

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 [PDF]

, 2004
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of ...
Erich A. Nigg, Francis A. Barr, Barr, FA, Neef, Rüdiger, Nigg, EA, Rüdiger Neef, Gruneberg, Ulrike, Honda, R, Ulrike Gruneberg, Nigg, Erich A., Neef, R, Reiko Honda, Honda, Reiko, Barr, Francis A.   +13 more
core   +1 more source

Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication

Cell Division, 2012
Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process.
Song Bing, Liu X Shawn, Liu Xiaoqi
doaj   +1 more source

Re-investigating PLK1 inhibitors as antimitotic agents

Molecular & Cellular Oncology, 2017
Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently determined that PLK1 is crucially required for entry into mitosis.
Quentin Delacour, Olivier Gavet
doaj   +1 more source

Identification of Plk1 type II inhibitors by structure-based virtual screening [PDF]

, 2009
Protein kinases are targets for drug development. Dysregulation of kinase activity leads to various diseases, e.g. cancer, inflammation, diabetes. Human polo-like kinase 1 (Plk1), a serine/threonine kinase, is a cancer-relevant gene and a potential drug ...
G Schneider, Keppner, Sarah, S Keppner, Proschak, Ewgenij, Spänkuch-Schmitt, Birgit, E Proschak, Schneider, Gisbert (Prof. Dr.), B Spänkuch   +7 more
core   +1 more source

Polo-like Kinase 1 (PLK1) Inhibitors Targeting Anticancer Activity

Kinases and Phosphatases
Polo-like kinase 1 (PLK1) is a serine/threonine kinase that orchestrates multiple critical events during mitosis, including centrosome maturation, spindle assembly, kinetochore–microtubule attachment, and cytokinesis.
Dina Bárbara Aguado-Herrera, Yudith Cañizares-Carmenate, Edeildo Ferreira da Silva-Júnior   +2 more
doaj   +1 more source

WAC Promotes Polo-like Kinase 1 Activation for Timely Mitotic Entry

Cell Reports, 2018
Summary: The key mitotic regulator Polo-like kinase 1 (Plk1) is activated during G2 phase by Aurora A kinase (AurkA)-mediated phosphorylation of its activation loop, which is important for timely mitotic entry.
Feifei Qi, Qinfu Chen, Hongxia Chen, Haiyan Yan, Binbin Chen, Xingfeng Xiang, Cai Liang, Qi Yi, Miao Zhang, Hankun Cheng, Zhenlei Zhang, Jun Huang, Fangwei Wang   +12 more
doaj   +1 more source

Downregulation of Polo-like kinase-1 (PLK-1) expression is associated with poor clinical outcome in uveal melanoma patients

Folia Histochemica et Cytobiologica, 2020
INTRODUCTION: Uveal melanoma (UM) is the most common primary eye tumour in adults. Distant metastases are seen in 50% of cases regardless of treatment, which contributes to high mortality rates.
Tomasz Berus, Anna Markiewicz, Katarzyna Kobylinska, Przemyslaw Biecek, Jolanta Orlowska-Heitzman, Bozena Romanowska-Dixon, Piotr Donizy   +6 more
doaj   +1 more source

p53-dependent repression of polo-like kinase-1 (PLK1) [PDF]

Cell Cycle, 2010
PLK1 is a critical mediator of G₂/M cell cycle transition that is inactivated and depleted as part of the DNA damage-induced G₂/M checkpoint. Here we show that downregulation of PLK1 expression occurs through a transcriptional repression mechanism and that p53 is both necessary and sufficient to mediate this effect.
McKenzie, Lynsey, King, Sharon, Marcar, Lynnette, Nicol, Samantha, Dias, Sylvia, Schumm, Kate, Robertson, Pamela, Bourdon, Jean-Christophe, Perkins, Neil, Fuller-Pace, Frances, Meek, David W.   +10 more
openaire   +3 more sources

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source