Results 41 to 50 of about 42,681 (176)

Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)

, 2012
Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progression.
Krupa S. Jani, D.S. Dalafave
core   +1 more source

KIF14 and citron kinase act together to promote efficient cytokinesis [PDF]

, 2006
Multiple mitotic kinesins and microtubule-associated proteins (MAPs) act in concert to direct cytokinesis (Glotzer, M. 2005. Science. 307:1735-1739). In anaphase cells, many of these proteins associate with an antiparallel array of microtubules termed ...
Erich A. Nigg, Chan, E. H. Y., Francis A. Barr, Eunice H.Y. Chan, Neef, Rüdiger, Nigg, EA, Xiuling Li, Rüdiger Neef, Gruneberg, Ulrike, Nigg, E. A., Gruneberg, U, Chan, EH, Chalamalasetty, R. B., Nigg, Erich A., Chalamalasetty, Ravindra B., Neef, R, Grüneberg, U., Chalamalasetty, RB, Barr, Francis A., Barr, FA, Li, Xiuling, Ravindra B. Chalamalasetty, Neef, R., Barr, F. A., Chan, Eunice H. Y., Ulrike Gruneberg, Li, X, Li, X. L.   +27 more
core   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Identification of Plk1 type II inhibitors by structure-based virtual screening

, 2009
Protein kinases are targets for drug development. Dysregulation of kinase activity leads to various diseases, e.g. cancer, inflammation, diabetes. Human polo-like kinase 1 (Plk1), a serine/threonine kinase, is a cancer-relevant gene and a potential drug ...
G Schneider, Keppner, Sarah, S Keppner, Proschak, Ewgenij, Spänkuch-Schmitt, Birgit, E Proschak, Schneider, Gisbert (Prof. Dr.), B Spänkuch   +7 more
core   +1 more source

Polo-Like Kinase 1 in the Life and Death of Cancer Cells [PDF]

Cell Cycle, 2003
The polo-like kinase family plays a vital role in many cell cycle related events. The family includes mammalian Plkl, Snk (Plk2), and Fnk/Prk (Plk3), Xenopus laevis Plxl,Drosophila polo, fission yeast Plol, and budding yeast Cdc5. These enzymes, in addition to a conserved kinase domain at the N-terminus, have highly conserved sequences called polo-box ...
Xiaoqi, Liu, Raymond L, Erikson
openaire   +2 more sources

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, EarlyView.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +1 more source

Comparative Response of Canine and Human Osteosarcoma Tumour Cell Lines to Molecularly Targeted Anticancer Agents at Clinically Relevant Exposures With Analysis of Genomic Biomarkers

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Osteosarcoma (OSA) is a primary bone tumour occurring in children but is also prevalent in large breed dogs. Canine OSA (cOSA) has long been viewed as analogous to human OSA (hOSA) with cOSA serving as a surrogate for development of therapeutic approaches to treat the rarer human form.
Daniel L. Gustafson, Kala A. Early, Maritza A. Morales, Klaudia A. Poplawski, Sunetra Das, Dawn L. Duval   +5 more
wiley   +1 more source

Marcadores moleculares e morfológicos da citocinese em Trypanosoma rangeli [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2013.O Trypanosoma rangeli é um protozoário que, embora estreitamente relacionado ao ...
Prestes, Elisa Beatriz
core