Results 21 to 30 of about 33,833,464 (200)

Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3. [PDF]

Biol Pharm Bull
Assay systems for evaluating compound protein-binding affinities are essential for developing agonists and/or antagonists. Targeting individual members of a protein family can be extremely important and for this reason it is critical to have methods for evaluating selectivity.
Tsuji K, Tamamura H, Burke TR.
europepmc   +3 more sources

SBE13, a newly identified inhibitor of inactive polo-like kinase 1 [PDF]

Journal of Cheminformatics, 2010
Poster presentation at 5th German Conference on Cheminformatics: 23. CIC-Workshop Goslar, Germany. 8-10 November 2009 Protein kinases are important targets for drug development.
Keppner Sarah, Proschak Ewgenij, Schneider Gisbert, Spänkuch B   +3 more
doaj   +2 more sources

An investigation of Plk1 PBD inhibitor KBJK557 as a tumor growth suppressor in non-small cell lung cancer

Journal of Analytical Science and Technology, 2022
Lung cancer is the second most commonly reported type of cancer worldwide. Approximately 80–85% of lung cancer occurrences are accounted by non-small cell lung cancer (NSCLC).
Pethaiah Gunasekaran, Gong-Hyeon Lee, Yeon Sil Hwang, Bon-Chul Koo, Eun Hee Han, Guel Bang, Yeo Kyung La, Sunghyun Park, Hak Nam Kim, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu   +11 more
doaj   +1 more source

Functional Dynamics of Polo-Like Kinase 1 at the Centrosome [PDF]

Molecular and Cellular Biology, 2009
Polo-like kinase 1 (Plk1) functions as a key regulator of mitotic events by phosphorylating substrate proteins on centrosomes, kinetochores, the mitotic spindle, and the midbody. Through mechanisms that are incompletely understood, Plk1 is released from and relocalizes to different mitotic structures as cells proceed through mitosis.
Kazuhiro, Kishi, Marcel A T M, van Vugt, Ken-ichi, Okamoto, Yasunori, Hayashi, Michael B, Yaffe   +4 more
openaire   +2 more sources

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U., Erich A. Nigg, Francis A. Barr, Neef, Rüdiger, Josephine Sutcliffe, Kopajtich, R., Rüdiger Neef, Nigg, E. A., Robert Kopajtich, Mayer, T. U., Thomas U. Mayer, Christian Preisinger, Preisinger, C., Neef, R., Sutcliffe, J., Barr, F. A., Nigg, Erich A., Sutcliffe, Josephine, Kopajtich, Robert, Preisinger, Christian, Barr, Francis A.   +20 more
core   +1 more source

Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536

Haematologica, 2011
Background In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells.
Barbara Peter, Karoline V. Gleixner, Sabine Cerny-Reiterer, Harald Herrmann, Viviane Winter, Emir Hadzijusufovic, Veronika Ferenc, Karina Schuch, Irina Mirkina, Hans-Peter Horny, Winfried F. Pickl, Leonhard Müllauer, Michael Willmann, Peter Valent   +13 more
doaj   +1 more source

Polo-like kinase-1 in DNA damage response

BMB Reports, 2014
Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1.
Sun-Yi, Hyun, Hyo-In, Hwang, Hyo-In, Hwan, Young-Joo, Jang   +3 more
openaire   +3 more sources

Multiple Roles of PLK1 in Mitosis and Meiosis

Cells, 2023
Cells are equipped with a diverse network of signaling and regulatory proteins that function as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell division. A key regulator of cell division is polo-like kinase 1 (PLK1),
Jaroslav Kalous, Daria Aleshkina
doaj   +1 more source

Synthesis and evaluation of small molecule-based derivatives as inhibitors of polo-box domain of polo-like kinase-1

Journal of Analytical Science and Technology, 2023
Objectives Polo-like kinase 1 (Plk1) is an important mitotic protein. In particular, this protein is highly overexpressed in many types of tumors and has been identified as a potential biomarker for the treatment and diagnosis of tumors. Plk1 is composed
Yeo Kyung La, Pethaiah Gunasekaran, Min Su Yim, Gong-Hyeon Lee, Yeon Sil Hwang, Kannan Damodharan, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu   +8 more
doaj   +1 more source

SETD2 non genomic loss of function in advanced systemic mastocytosis is mediated by an Aurora kinase A/MDM2 axis and can be therapeutically targeted

Biomarker Research, 2023
Background The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3).
Manuela Mancini, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, Michela Rondoni, Chiara Sartor, Samantha Bruno, Livio Pagano, Marianna Criscuolo, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Tosi, Michel Arock, Peter Valent, Michele Cavo, Simona Soverini   +15 more
doaj   +1 more source