Results 21 to 30 of about 42,681 (176)
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]
, 2015 Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Timm Maier +15 more
core +1 more source
On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]
, 2015 Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core +1 more source
Polo-like kinase-1 in DNA damage response
BMB Reports, 2014 Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1.
Sun-Yi, Hyun +3 more
openaire +3 more sources
A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas [PDF]
Frontiers in Oncology, 2019 Rhabdomyosarcomas are the most common pediatric soft tissue sarcoma and are a major cause of death from cancer in young patients requiring new treatment options to improve outcomes. High-risk patients include those with metastatic or relapsed disease and tumors with PAX3-FOXO1 fusion genes that encode a potent transcription factor that drives ...
Susanne A. Gatz +10 more
openaire +6 more sources
Modulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention [PDF]
Pharmaceutical Research, 2010 Naturally occurring agents have always been appreciated for their medicinal value for both their chemopreventive and therapeutic effects against cancer. In fact, the majority of the drugs we use today, including the anti-cancer agents, were originally derived from natural compounds, either in their native form or modified to enhance their ...
Travis L, Schmit +2 more
openaire +2 more sources
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 [PDF]
, 2004 Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of ...
Erich A. Nigg +13 more
core +1 more source
p53-dependent repression of polo-like kinase-1 (PLK1) [PDF]
Cell Cycle, 2010 PLK1 is a critical mediator of G₂/M cell cycle transition that is inactivated and depleted as part of the DNA damage-induced G₂/M checkpoint. Here we show that downregulation of PLK1 expression occurs through a transcriptional repression mechanism and that p53 is both necessary and sufficient to mediate this effect.
McKenzie, Lynsey +10 more
openaire +3 more sources
Identification of Rictor as a Novel Substrate of Polo-like kinase 1 [PDF]
Cell Cycle, 2015 Plk1 has been essentially described as a critical regulator of many mitotic events. However, increasing evidence supports the notion that its molecular functions are not restricted to the cell cycle. In particular, recent reports suggest the existence of a molecular and functional link between Plk1 and the mammalian target of rapamycin (mTOR) pathway ...
Tian, Shao, Xiaoqi, Liu
openaire +2 more sources
The function of mammalian Polo-like kinase 1 in microtubule nucleation [PDF]
Proceedings of the National Academy of Sciences, 2011 Mitotic spindle, the structure essential for equal partitioning of the chromosomes into daughter cells, is of pivotal importance for the maintenance of genomic stability during cell division (1). Microtubules (MTs) that constitute the mitotic spindle are polymers of α- and β-tubulin dimers. Generation of MT starts with a process called MT nucleation in
Dazhong, Xu, Wei, Dai
openaire +2 more sources
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis [PDF]
, 2005 Several kinases phosphorylate vimentin, the most common intermediate filament protein, in mitosis. Aurora-B and Rho-kinase regulate vimentin filament separation through the cleavage furrow-specific vimentin phosphorylation.
Erich A. Nigg +19 more
core +1 more source