Results 11 to 20 of about 33,833,464 (200)
The balance of Polo-like kinase 1 in tumorigenesis [PDF]
Cell Division, 2009 Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly,
Yu Xiaochun, Lu Lin-Yu
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Polo-like kinase 1 as target for cancer therapy [PDF]
Experimental Hematology & Oncology, 2012 Polo-like kinase 1 (Plk1) is an interesting molecule both as a biomarker and as a target for highly specific cancer therapy for several reasons. Firstly, it is over-expressed in many cancers and can serve as a biomarker to monitor treatment efficacy of ...
Weiß Lily, Efferth Thomas
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PLK1 (polo-like kinase 1 (Drosophila)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PLK1 (polo-like kinase 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is implicated.
AE Erson, EM Petty
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Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)
Bioinformatics and Biology Insights, 2012 Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progression.
Krupa S. Jani, D.S. Dalafave
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Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells [PDF]
Haematologica, 2013 This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Stefanie A. Hartsink-Segers +8 more
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Getting in and out of mitosis with Polo-like kinase-1 [PDF]
Oncogene, 2005 Research in different species has shown that Polo-like kinases are essential for successful cell division. In human cells, Polo-like kinase-1 (Plk1) has been implicated in the regulation of different processes, including mitotic entry, spindle formation and cytokinesis. Recently, a range of new downstream targets of Plk1 has been identified, as well as
Vugt, M.A.T.M. van, Medema, R.H.
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Polo like kinase 2 tumour suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer [PDF]
, 2012 The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers. The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian ...
Mcneish, I. +6 more
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A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas [PDF]
Frontiers in Oncology, 2019 Rhabdomyosarcomas are the most common pediatric soft tissue sarcoma and are a major cause of death from cancer in young patients requiring new treatment options to improve outcomes. High-risk patients include those with metastatic or relapsed disease and
Susanne A. Gatz +10 more
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Polo-Like Kinase-1: Activity Measurement and RNAi-Mediated Knockdown [PDF]
, 2004 Polo-like kinase-1 (Plk-1) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. In this chapter we review those multiple functions of Plk-1 and describe the methods routinely used in our laboratory to purify Plk-1 from cellular lysates and measure Plk-1 kinase activity in vitro.
Vugt, M.A.T.M. van, Medema, R.H.
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The CINs of Polo-Like Kinase 1 in Cancer [PDF]
Cancers, 2020 Polo-like kinase 1 (PLK1) is overexpressed near ubiquitously across all cancer types and dysregulation of this enzyme is closely tied to increased chromosomal instability and tumor heterogeneity. PLK1 is a mitotic kinase with a critical role in maintaining chromosomal integrity through its function in processes ranging from the mitotic checkpoint ...
Chelsea E. Cunningham +5 more
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