Results 11 to 20 of about 42,681 (176)
Getting in and out of mitosis with Polo-like kinase-1 [PDF]
Oncogene, 2005 Research in different species has shown that Polo-like kinases are essential for successful cell division. In human cells, Polo-like kinase-1 (Plk1) has been implicated in the regulation of different processes, including mitotic entry, spindle formation ...
Medema, R.H., Vugt, M.A.T.M. van
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PLK1 (polo-like kinase 1 (Drosophila)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2005 Review on PLK1 (polo-like kinase 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
Erson, AE, Petty, EM
core +2 more sources
The balance of Polo-like kinase 1 in tumorigenesis [PDF]
Cell Division, 2009 Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly,
Yu, Xiaochun +5 more
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Polo-like kinase 1 as target for cancer therapy [PDF]
Experimental Hematology & Oncology, 2012 Polo-like kinase 1 (Plk1) is an interesting molecule both as a biomarker and as a target for highly specific cancer therapy for several reasons. Firstly, it is over-expressed in many cancers and can serve as a biomarker to monitor treatment efficacy of ...
Weiß Lily +3 more
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Polo-like kinase-1: activity measurement and RNAi-mediated knockdown
, 2005 Polo-like kinase-1 (Plk-1) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. In this chapter we review those multiple functions of Plk-1 and describe the methods routinely used in our laboratory to
Medema, R.H., Vugt, M.A.T.M. van
core +5 more sources
Polo-like kinase-1 is a target of the DNA damage checkpoint
Nature Cell Biology, 2000 Polo-like kinases (PLKs) have an important role in several stages of mitosis. They contribute to the activation of cyclin B/Cdc2 and are involved in centrosome maturation and bipolar spindle formation at the onset of mitosis.
Nigg, E.A. +14 more
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The CINs of Polo-Like Kinase 1 in Cancer [PDF]
Cancers, 2020 Polo-like kinase 1 (PLK1) is overexpressed near ubiquitously across all cancer types and dysregulation of this enzyme is closely tied to increased chromosomal instability and tumor heterogeneity. PLK1 is a mitotic kinase with a critical role in maintaining chromosomal integrity through its function in processes ranging from the mitotic checkpoint ...
Chelsea E. Cunningham +5 more
openaire +2 more sources
Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3. [PDF]
Biol Pharm BullAssay systems for evaluating compound protein-binding affinities are essential for developing agonists and/or antagonists. Targeting individual members of a protein family can be extremely important and for this reason it is critical to have methods for evaluating selectivity.
Tsuji K, Tamamura H, Burke TR.
europepmc +3 more sources
Functional Dynamics of Polo-Like Kinase 1 at the Centrosome [PDF]
Molecular and Cellular Biology, 2009 Polo-like kinase 1 (Plk1) functions as a key regulator of mitotic events by phosphorylating substrate proteins on centrosomes, kinetochores, the mitotic spindle, and the midbody. Through mechanisms that are incompletely understood, Plk1 is released from and relocalizes to different mitotic structures as cells proceed through mitosis.
Kazuhiro, Kishi +4 more
openaire +2 more sources
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]
, 2003 We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U. +20 more
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