Results 21 to 30 of about 9,921 (221)

Grabbing Plk1 by the PBD [PDF]

Molecular Cell, 2006
A new centromeric protein termed PBIP1 was identified that recruits Plk1 to the kinetochores. In the November 3 issue of Molecular Cell, show that Plk1 phosphorylates PBIP1 on threonine 78, creating its own high-affinity docking site for the polo-box domain (PBD).
Dai, Wei, Wang, Xiaoxing
openaire   +2 more sources

RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPKα2 to activate oxidative phosphorylation and fatty acid oxidation

Journal of experimental & clinical cancer research : CR, 2023
Background More than 90% of the mortality of triple-negative breast cancer (TNBC) patients is attributed to cancer metastasis with organotropism. The lung is a frequent site of TNBC metastasis.
Shaojie Cheng, Xueying Wan, Liping Yang, Yilu Qin, Shanchun Chen, Yongcan Liu, Yan Sun, Yuxiang Qiu, Luyi Huang, Qizhong Qin, Xiao-Jiang Cui, Ming-Jun Wu, Manran Liu   +12 more
semanticscholar   +1 more source

PLK1 regulating chemoradiotherapy sensitivity of esophageal squamous cell carcinoma through pentose phosphate pathway/ferroptosis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
BACKGROUND Esophageal squamous cell carcinoma (ESCC) is the most common pathological type of esophageal cancer in China, accounting for more than 90 %.
Mengnan Zhao, Tao Lu, Guoshu Bi, Zheng-Yang Hu, Jia-Qi Liang, Yunyi Bian, Mingxiang Feng, C. Zhan   +7 more
semanticscholar   +1 more source

PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Cell Death and Disease, 2023
Protein diversity due to alternative mRNA splicing or post-translational modifications (PTMs) plays a vital role in various cellular functions. The mitotic kinases polo-like kinase 1 (PLK1) and Aurora B (AURKB) phosphorylate survivin, an inhibitor of ...
Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, J. Krishnamurthy, R. C. Turaga, T. Nguyen, Xiaoxian Li, R. Aneja   +7 more
semanticscholar   +1 more source

PLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1

Cell Death Discovery, 2023
Glioma stem cells (GSCs) are the important cause of tumorigenesis, recurrence, and chemo(radio)resistance in glioma. Targeting GSCs helps improve the outcomes of glioma treatment.
Xuetao Li, Guangliang Chen, Bin Liu, Zhennan Tao, Yuehua Wu, Kai Zhang, Zibin Feng, Yu-Lun Huang, Hao Wang   +8 more
semanticscholar   +1 more source

Present and Future Perspective on PLK1 Inhibition in Cancer Treatment

Frontiers in Oncology, 2022
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine kinase family. PLK1 has a key role in the progression of mitosis and recent evidence suggest its important involvement in regulating the G2/M checkpoint, in DNA ...
M. Chiappa, Serena Petrella, G. Damia, M. Broggini, F. Guffanti, F. Ricci   +5 more
semanticscholar   +1 more source

CCNE1 and PLK1 Mediate Resistance to Palbociclib in HR+/HER2− Metastatic Breast Cancer

Clinical Cancer Research, 2023
Purpose: In hormone receptor–positive (HR+)/HER2− metastatic breast cancer (MBC), it is imperative to identify patients who respond poorly to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and to discover therapeutic targets to reverse this resistance.
A. Guerrero-Zotano, S. Belli, C. Zielinski, M. Gil-Gil, A. Fernández-Serra, M. Ruíz-Borrego, E. C. Ciruelos Gil, J. Pascual, M. Muñoz-Mateu, B. Bermejo, Mireia Margelí Vila, A. Antón, L. Murillo, Bella Nissenbaum, Yuan Liu, J. Herranz, D. Fernández-García, R. Caballero, J. López-Guerrero, R. Bianco, L. Formisano, N. Turner, Miguel Martín   +22 more
semanticscholar   +1 more source

3D-QSAR Studies, Molecular Docking, Molecular Dynamic Simulation, and ADMET Proprieties of Novel Pteridinone Derivatives as PLK1 Inhibitors for the Treatment of Prostate Cancer

Life, 2023
Overexpression of polo-like kinase 1 (PLK1) has been found in many different types of cancers. With its essential role in cell proliferation, PLK1 has been determined to be a broad-spectrum anti-cancer target.
M. Er-rajy, Mohamed El fadili, Hamada Imtara, Aamir Saeed, Abid ur Rehman, Sara Zarougui, Shaef A. Abdullah, Ahmad Alahdab, M. Parvez, M. Elhallaoui   +9 more
semanticscholar   +1 more source

PLK1-mediated phosphorylation of β-catenin enhances its stability and transcriptional activity for extracellular matrix remodeling in metastatic NSCLC

Theranostics, 2023
Rationale: β-catenin is a component for cell adhesion and a transcriptional coactivator in epithelial-mesenchymal transition (EMT). Previously we found that catalytically active PLK1 drives EMT in non-small cell lung cancer (NSCLC), upregulating ...
Da-Eun Kim, Sol-bi Shin, Chang-Hyeon Kim, Yeo-Bin Kim, Hyun-Ji Oh, H. Yim   +5 more
semanticscholar   +1 more source

A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key [PDF]

Open Biology, 2018
The Polo kinase is an essential regulator of cell division. Its ability to regulate multiple events at distinct subcellular locations and times during mitosis is remarkable. In the last few years, a much clearer mechanistic understanding of the functions
Lionel Pintard, Vincent Archambault
doaj   +1 more source