Results 31 to 40 of about 9,921 (221)

Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling

Experimental Hematology & Oncology, 2023
Background KRAS^G12C inhibitors (KRAS^G12Ci) AMG510 and MRTX849 have shown promising efficacy in clinical trials and been approved for the treatment of KRAS^G12C-mutant cancers.
Yafang Wang, Ming-Yue Yao, Cheng Li, Kexin Yang, X. Qin, Lansong Xu, Shang-Xuan Shi, Cheng-Cheng Yu, Xiangjun Meng, Chengying Xie   +9 more
semanticscholar   +1 more source

Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death

Frontiers in Pharmacology, 2021
α/β-Tubulin inhibitors that alter microtubule (MT) dynamics are commonly used in cancer therapy, however, these inhibitors also cause severe side effects such as peripheral neuropathy.
Haruna Ebisu, Kana Shintani, Takumi Chinen, Takumi Chinen, Takumi Chinen, Yoko Nagumo, Shuya Shioda, Taisei Hatanaka, Akira Sakakura, Ichiro Hayakawa, Hideo Kigoshi, Takeo Usui, Takeo Usui   +12 more
doaj   +1 more source

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis [PDF]

, 2005
Several kinases phosphorylate vimentin, the most common intermediate filament protein, in mitosis. Aurora-B and Rho-kinase regulate vimentin filament separation through the cleavage furrow-specific vimentin phosphorylation.
Erich A. Nigg, Andreas Uldschmid, Hanisch, Anja, Uldschmid, Andreas, Takashi Oguri, Takai, Yasushi, Tomoya Yamaguchi, Yasushi Takai, Masaki Inagaki, Goto, Hidemasa, Tomoya Yokoyama, Anja Hanisch, Hidemasa Goto, Silljé, Herman, Herman Silljé, Oguri, Takashi, Yamaguchi, Tomoya, Nigg, Erich A., Inagaki, Masaki, Yokoyama, Tomoya   +19 more
core   +1 more source

Ubiquitin‐specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1

Cancer Science, 2023
Ubiquitin‐specific peptidase 24 (USP24), a member of the deubiquitinase family, plays an important role in tumor regulation. However, the role of USP24 in gastric cancer (GC) is unknown. The aim of our study was to explore the role of USP24 in GC to seek
Xiao-Fei Zhi, Song Jiang, Jiaxuan Zhang, J. Qin   +3 more
semanticscholar   +1 more source

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.

PLoS ONE, 2012
Polo-like kinase (Plk1) plays a central role in regulating the cell cycle. Plk1-mediated phosphorylation is essential for centrosome maturation, and for numerous mitotic events.
Tamina Seeger-Nukpezah, Max C Liebau, Katja Höpker, Tobias Lamkemeyer, Thomas Benzing, Erica A Golemis, Bernhard Schermer   +6 more
doaj   +1 more source

Comparative Analysis of a FRET-based PLK1 Kinase Assay to Identify PLK1 inhibitors for Chemotherapy [PDF]

Anticancer Research, 2017
Advanced techniques for detecting kinase inhibitors are in demand due to limitations of traditional approaches. Here, we used a fluorescence resonance energy transfer (FRET)-based kinase assay, a sensitive fluorescence turn-on biosensing platform, to identify a Polo-like kinase 1 (PLK1) inhibitor.
Sol-Bi, Shin, Sang-Uk, Woo, Young-Joo, Lee, Hyungshin, Yim   +3 more
openaire   +2 more sources

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells [PDF]

, 2011
High attrition rates of novel anti-cancer drugs highlight the need for improved models to predict toxicity. Although polo-like kinase 1 (Plk1) inhibitors are attractive candidates for drug development, the role of Plk1 in primary cells remains widely ...
Kappel, Sven, Eckhard Wolf, Kreft, B., Martin Bergmann, Martin Klingenspor, Prinz, Florian, Kurunci-Csacsko, Elisabeth, Nicole Sänger, Knecht, R., Jost Seibler, Thure Adler, Florian Prinz, Strebhardt, K., Hrabě de Angelis, M., Busch, D.H., Monika Raab, Sanhaji, Mourad, Yves Matthess, Martin Hrabě de Angelis, Bergmann, M., Adler, Thure, Seibler, Jost, Rathkolb, Birgit, Irene Esposito, Dirk H. Busch, Rathkolb, B., Rozman, J., Rozman, Jan, Esposito, Irene, Yuan, J., Andrea Krämer, Fuchs, H., Calzada-Wack, Julia, Jan Rozman, Rainald Knecht, Esposito, I., Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Knecht, Rainald, Valérie Gailus-Durner, Wolf, E., Prinz, F., Sänger, Nicole, Krämer, A., Calzada-Wack, J., Gailus-Durner, V., Kappel, S., Helmut Fuchs, Kurunci-Csacsko, E., Klingenspor, Martin, Yuan, Juping, Matthess, Yves, Busch, Dirk H., Klaus Strebhardt, Strebhardt, Klaus, Juping Yuan, Kreft, Bertolt, Julia Calzada-Wack, Sven Kappel, Krämer, Andrea, Klingenspor, M., Matthess, Y., Bergmann, Martin, Birgit Rathkolb, Adler, T., Elisabeth Kurunci-Csacsko, Sänger, N., Raab, Monika, Bertolt Kreft, Fuchs, Helmut, Wolf, Eckhard, Mourad Sanhaji, Raab, M., Sanhaji, M., Seibler, J.   +74 more
core   +1 more source

Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis

Cell Death and Disease, 2023
The prevalence of chronic kidney disease (CKD) has been increasing over the past decades. However, no effective therapies are available for delaying or curing CKD.
Yang Du, Yaqiong Shang, Yun Qian, Yan Guo, Shuang Chen, Xiuli Lin, Weidong Cao, Xiaomei Tang, An-Dong Zhou, Songming Huang, A. Zhang, Zhanjun Jia, Yue Zhang   +12 more
semanticscholar   +1 more source

Tumor inhibition by genomically integrated inducible RNAi-cassettes [PDF]

, 2006
RNA interference (RNAi) has emerged as a powerful tool to induce loss-of-function phenotypes by post-transcriptional silencing of gene expression. In this study we wondered whether inducible RNAi-cassettes integrated into cellular DNA possess the power ...
Kappel, Sven, Zimmer, Brigitte, Brigitte Zimmer, Manfred Kaufmann, Yves Matthess, Matthess, Yves, Klaus Strebhardt, Strebhardt, Klaus, Kaufmann, Manfred   +8 more
core   +1 more source

Targeting Plk1 sensitizes pancreatic cancer to immune checkpoint therapy

Cancer Research, 2022
Polo-like kinase 1 (Plk1) plays an important role in cell cycle regulation. Recent work has suggested that Plk1 could be a biomarker of gemcitabine response in pancreatic ductal adenocarcinoma (PDAC).
Zhuangzhuang Zhang, Lijun Cheng, J. Li, Qi Qiao, Anju Karki, Derek B. Allison, Nuha Shaker, Kunyu Li, S. Utturkar, Nadia Atallah Lanman, Xiongjian Rao, P. Rychahou, Daheng He, S. Konieczny, Chi Wang, Qing-Chun Shao, B. Evers, Xiaoqi Liu   +17 more
semanticscholar   +1 more source