Results 61 to 70 of about 9,921 (221)

PLK1 overexpression as a dual-role biomarker and therapeutic vulnerability in pulmonary adenocarcinoma [PDF]

PeerJ
Background PLK1 is associated with various malignant tumors, but its correlation with lung adenocarcinoma (LUAD) remains unclear. This research seeks to explore the differences in PLK1 expression in LUAD and evaluate the relationship between PLK1 ...
Lukuan You, Yinmei Xu, Yankan Fu, Jianxiong Li   +3 more
doaj   +2 more sources

Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300/H3K27ac/PLK1 axis.

Pharmacological Research
Many inflammatory disorders, including diabetic kidney disease (DKD), are associated with pyroptosis, a type of inflammation-regulated cell death. The purpose of this work was to ascertain the effects of apabetalone, which targets BRD4, a specific ...
Min Wang, Zhaohui Huang, Xin Li, Ping He, He Sun, Yali Peng, Qiu-Ling Fan   +6 more
semanticscholar   +1 more source

Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

eLife, 2021
Dysregulation of tumor-relevant proteins may contribute to human hepatocellular carcinoma (HCC) tumorigenesis. FBXO45 is an E3 ubiquitin ligase that is frequently elevated expression in human HCC.
Xiao-Tong Lin, Hongfu Yu, Lei Fang, Ye Tan, Ze-Yu Liu, Di Wu, Jie Zhang, Hao-Jun Xiong, Chuanming Xie   +8 more
semanticscholar   +1 more source

Pan-Cancer Transcriptomic Analysis Identifies PLK1 Crucial for the Tumorigenesis of Clear Cell Renal Cell Carcinoma

Journal of Inflammation Research, 2022
Yiguan Qian,* Yang Li,* Ke Chen,* Ning Liu, Xi Hong, Di Wu, Zheng Xu, Liuhua Zhou, Luwei Xu, Ruipeng Jia, Yu-Zheng Ge Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China&ast ...
Qian Y, Li Y, Chen K, Liu N, Hong X, Wu D, Xu Z, Zhou L, Xu L, Jia R, Ge YZ   +10 more
doaj  

The substrates of Plk1, beyond the functions in mitosis [PDF]

Protein & Cell, 2010
Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication ...
X Shawn, Liu, Bing, Song, Xiaoqi, Liu
openaire   +2 more sources

DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target

Journal of Translational Medicine
Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal role in regulating the cell cycle and implicate in tumorigenesis and progression of various cancers.
Maojian Chen, Shaoping Zhang, Fan Wang, Junyi He, Wei Jiang, Li Zhang   +5 more
semanticscholar   +1 more source

PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair

Nucleic Acids Research, 2021
Polo-like kinase 1 (PLK1) is a master kinase that regulates cell cycle progression. How its enzymatic activity is regulated in response to DNA damage is not fully understood.
Bin Peng, Ruifeng Shi, Jing Bian, Yuwei Li, Peipei Wang, Hailong Wang, Ji Liao, Wei-Guo Zhu, Xingzhi Xu   +8 more
semanticscholar   +1 more source

WAC Promotes Polo-like Kinase 1 Activation for Timely Mitotic Entry

Cell Reports, 2018
Summary: The key mitotic regulator Polo-like kinase 1 (Plk1) is activated during G2 phase by Aurora A kinase (AurkA)-mediated phosphorylation of its activation loop, which is important for timely mitotic entry.
Feifei Qi, Qinfu Chen, Hongxia Chen, Haiyan Yan, Binbin Chen, Xingfeng Xiang, Cai Liang, Qi Yi, Miao Zhang, Hankun Cheng, Zhenlei Zhang, Jun Huang, Fangwei Wang   +12 more
doaj   +1 more source

Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

Cell Reports
SUMMARY Bromodomain-containing protein 4 (BRD4) has emerged as a promising therapeutic target in prostate cancer (PCa). Understanding the mechanisms of BRD4 stability could enhance the clinical response to BRD4-targeted therapy.
Yanquan Zhang, Ka-Wing Fong, Feng-Yi Mao, Ruixin Wang, Derek B. Allison, Dana Napier, Daheng He, Jin-Peng Liu, Ye-Qing Zhang, Jing Chen, Yi-Fan Kong, Chaohao Li, Guang-Bing Li, Jinghui Liu, Zhiguo Li, Hai-Ning Zhu, Chi Wang, Xiaoqi Liu   +17 more
semanticscholar   +1 more source

PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells

Frontiers in Cell and Developmental Biology, 2022
Intervertebral disc degeneration (IVDD) is the primary cause of low back pain; however, the molecular mechanisms involved in the pathogenesis of IVDD are not fully understood. Polo-like kinase 1 (PLK1) plays numerous roles in the cell cycle, including in
Zhenlei Zhang, Zhenlei Zhang, Yizhen Huang, Yizhen Huang, Nizhen Xu, Jianle Wang, Jianle Wang, Teng Yao, Teng Yao, Yining Xu, Yining Xu, Di Qiao, Di Qiao, Jun Gao, Jun Gao, Shuying Shen, Shuying Shen, Jianjun Ma, Jianjun Ma, Jianjun Ma   +19 more
doaj   +1 more source