Results 81 to 90 of about 9,921 (221)
Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh +22 more
wiley +1 more source
Entwicklung und Etablierung von induzierbaren RNAi-Systemen zur Regulierung der Expression von Polo-like Kinase 1 (Plk1) in vitro und in vivo [PDF]
, 2007 RNA-Interferenz (RNAi) erlangte eine herausragende Bedeutung zum Studium der Genfunktion, nachdem auch in Säugersystemen gezeigt wurde, daß durch Applikation von 21 nt langen siRNAs (small interfering RNAs) eine Sequenz-spezifische Degradierung der mRNA ...
Kappel, Sven
core
Science Advances, 2022 Bloom’s syndrome is caused by inactivation of the BLM helicase, which functions with TOP3A and RMI1-2 (BTR complex) to dissolve recombination intermediates and avoid somatic crossing-over. We show here that crossover avoidance by BTR further requires the
Chiara Balbo Pogliano +12 more
semanticscholar +1 more source
Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation
Nature CommunicationsPolo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division, and its activity is tightly regulated throughout the cell cycle.
Elizabeth M. Black +7 more
doaj +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
AHR and PLK1 are important for LUAD progression.
, 2023 A, Comparison of AHR and PLK1 expressions among normal lung, LUAD, LUSC, and SCLC cell lines using data from the DepMap database. Statistical methods: Welch’s ANOVA test following multiple comparisons (AHR); one-way ANOVA following multiple comparisons ...
Chi Wang (131921) +18 more
core +1 more source
Journal of Cellular and Molecular Medicine, 2021 Sepsis and sepsis‐induced skeletal muscle atrophy are common in patients in intensive care units with high mortality, while the mechanisms are controversial and complicated.
Ying-Ya Cao +7 more
semanticscholar +1 more source
RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
Advanced Science, EarlyView.At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo +10 more
wiley +1 more source
PLK1 Inhibitors: Setting the Mitotic Death Trap [PDF]
Current Biology, 2007 Polo-like kinase 1 (Plk1) regulates mitotic progression in all eukaryotes and has been implicated in the transformation of human cells. Analysis of the cytological and anti-tumor activities of BI 2536, a novel, selective pharmacological inhibitor of Plk1, has connected chemistry and biology to the bedside.
Plyte, Simon, Musacchio, Andrea
openaire +3 more sources
Plk1 T214V does not rescue Plk1 functions.
, 2016 (A) Plk1 T214V is not unfolded and can bind ATP. Recombinant His-tagged Plk1 kinase domains with and without T214V mutation were assessed for proper protein folding using Differential Scanning Fluorimetry. Equivalent conditions except where indicated. n =
Natalie G. Trueman (2503096) +3 more
core +1 more source