Results 71 to 80 of about 9,921 (221)

Use of the Novel Plk1 Inhibitor ZK-Thiazolidinone to Elucidate Functions of Plk1 in Early and Late Stages of Mitosis [PDF]

Molecular Biology of the Cell, 2007
Polo-like kinase 1 (Plk1) is a key regulator of mitotic progression and cell division in eukaryotes. It is highly expressed in tumor cells and considered a potential target for cancer therapy. Here, we report the discovery and application of a novel potent small-molecule inhibitor of mammalian Plk1, ZK-Thiazolidinone (TAL).
Santamaria, Anna, Neef, Rüdiger, Eberspächer, Uwe, Eis, Knut, Husemann, Manfred, Mumberg, Dominik, Prechtl, Stefan, Schulze, Volker, Siemeister, Gerhard, Wortmann, Lars, Barr, Francis A., Nigg, Erich A.   +11 more
openaire   +4 more sources

PLK1 inhibition sensitizes breast cancer cells to radiation via suppressing autophagy.

International Journal of Radiation Oncology, Biology, Physics, 2021
PURPOSE Polo-like kinase 1 (PLK1) is a protein kinase that is overexpressed in breast cancer and may represent an attractive target for breast cancer treatment.
Baiyao Wang, Xiao-Ting Huang, Huiping Liang, Hongli Yang, Zhao-Ze Guo, Meiling Ai, Jiangyu Zhang, Muhammad Khan, Yun-Hong Tian, Quanquan Sun, Z. Mao, Rong-Hui Zheng, Ya-Wei Yuan   +12 more
semanticscholar   +1 more source

Exogenous proline enhances susceptibility of NSCLC to cisplatin via metabolic reprogramming and PLK1-mediated cell cycle arrest

Frontiers in Pharmacology, 2022
The occurrence of cisplatin resistance is still the main factor limiting the therapeutic effect of non-small cell lung cancer (NSCLC). It is urgent to elucidate the resistance mechanism and develop novel treatment strategies.
Bingjie Han, Yuanyuan Sun, Xiaofen Zhang, Ping Yue, Meiling Tian, Dan Yan, Fanxiang Yin, Bo Qin, Yi Zhao   +8 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD

PLoS Genetics
PLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the efficacy of immunotherapy, highlighting its important role in the regulation of tumor immunity.
Yi-Fan Kong, Chaohao Li, Jinpeng Liu, Sai Wu, Min Zhang, Derek B. Allison, Faisal Hassan, Daheng He, Xin-Yi Wang, Feng-Yi Mao, Qiongsi Zhang, Yanquan Zhang, Zhiguo Li, Chi Wang, Xiaoqi Liu   +14 more
semanticscholar   +1 more source

Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis

npj Systems Biology and Applications, 2021
Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including altered Plk1 and p53 ...
Yongwoon Jung, P. Kraikivski, Sajad Shafiekhani, S. Terhune, R. Dash   +4 more
semanticscholar   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G(2) delay and mitotic defects [PDF]

, 2013
Work by JP is funded by a Royal Society University Research Fellowship award. Experiments carried out by MBP were supported by the Department of Pathology, Albert Einstein College of Medicine / Montefiore Medical Center.The development of clinically ...
Parish, Joanna, Kawachi, Nicole, Loudig, Olivier, Feeney, Katherine, Antkowiak, Maciej, Prystowsky, Michael, Wasson, Christopher, Parish, Joanna; id_orcid, Willmott, Michelle, Montagna, Cristina   +9 more
core   +1 more source

PLK1 regulates microRNA biogenesis through Drosha phosphorylation

, 2023
Polo-Like Kinase 1 (PLK1), a key mediator of cell-cycle progression, is associated with poor prognosis and is a therapeutic target in a number of malignancies.
Taylor, Molly, Bevan, Charlotte, Claire Emily Fletcher, Charlotte Lynne Bevan, Fletcher, Claire, Molly Ann Taylor   +5 more
core   +1 more source

The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET

Science Signaling, 2022
Increased abundance of polo-like kinase 1 (PLK1) is observed in various tumor types, particularly in lung adenocarcinoma (LUAD). Here, we found that PLK1 accelerated the progression of LUAD through a mechanism that was independent of its role in ...
Yi-Fan Kong, Derek B. Allison, Qiongsi Zhang, Daheng He, Yuntong Li, Feng-Yi Mao, Chaohao Li, Zhiguo Li, Yanquan Zhang, Jianlin Wang, Chi Wang, C. Brainson, Xiaoqi Liu   +12 more
semanticscholar   +1 more source