Results 91 to 100 of about 9,921 (221)

Recent Progress on the Localization of PLK1 to the Kinetochore and Its Role in Mitosis

International Journal of Molecular Sciences, 2022
The accurate distribution of the replicated genome during cell division is essential for cell survival and healthy organismal development. Errors in this process have catastrophic consequences, such as birth defects and aneuploidy, a hallmark of cancer ...
Taekyung Kim
semanticscholar   +1 more source

Exploring the anti-gastric cancer mechanisms of Diosgenin through integrated network analysis, bioinformatics, single-cell sequencing, and cell experiments

Frontiers in Pharmacology
BackgroundTo comprehensively investigate the mechanism of action of Diosgenin elements against gastric cancer (GC).MethodsTargets of Diosgenin were collected from six databases, and enrichment analysis was used to identify its associated diseases and ...
Zhangjun Yun, Zhangjun Yun, Qianru Yang, Qianru Yang, Chengyuan Xue, Chengyuan Xue, Yang Shen, Liyuan Lv, Suicai Mi, Li Hou   +9 more
doaj   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines

, 2018
International audiencePolo-like kinases (Plks) define a highly conserved family of Ser/Thr kinases with crucial roles in the regulation of cell division. Here we show that Plk1 is cleaved by caspase 3, but not by other caspases in different hematopoietic
Parola, Julien, Boulakirba, Sonia, Furstoss, Nathan, Aira-Diaz, Lazaro, Luciano, Frederic, Robert, Guillaume, Orange, François, Pagès, Gilles, Zerhouni, Marwa, Auberger, Patrick, Savy, Coline, Marchetti, Sandrine, Ambrosetti, Damien, Calleja, Anne, Jacquel, Arnaud, Lacas-Gervais, Sandra, Dufies, Maeva   +16 more
core   +1 more source

PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling

Molecular Medicine, 2022
Background Intestinal barrier integrity in the pathogenesis of sepsis is critical. Despite an abundance of evidence, the molecular mechanism of the intestinal barrier in sepsis pathology remains unclear.
Ying Cao, Yuan Zhang, Wuyun Gerile, Yan Guo, Li-na Wu, Li-li Wu, K. Song, Wei-Hua Lu, Jian-bo Yu   +8 more
semanticscholar   +1 more source

SUMOylation Promotes Nuclear Import and Stabilization of Polo-like Kinase 1 to Support Its Mitotic Function

Cell Reports, 2017
As a pivotal mitotic regulator, polo-like kinase 1 (PLK1) is under highly coordinated and multi-layered regulation. However, the pathways that control PLK1’s activity and function have just begun to be elucidated.
Donghua Wen, Jianguo Wu, Lei Wang, Zheng Fu   +3 more
doaj   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

MicroRNA‐23a‐3p promotes macrophage M1 polarization and aggravates lipopolysaccharide‐induced acute lung injury by regulating PLK1/STAT1/STAT3 signalling

International journal of experimental pathology (Print), 2022
Macrophage polarization is an important effector process in acute lung injury (ALI) induced by sepsis. MicroRNAs (miRNAs) have emerged as important players in regulating ALI process. Here, we showed that elevated microRNA‐23a‐3p (miR‐23a‐3p) promoted LPS‐
Tao Jiang, Li Sun, Junxiao Zhu, Ning Li, Hai-Bo Gu, Ying Zhang, Miaomiao Li, Jiayao Xu   +7 more
semanticscholar   +1 more source

Self-priming of Plk1 binding to BubR1 ensures accurate mitotic progression

Communications Biology
Plk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors.
Chunlin Song, Mingzhe Zhang, Thomas Kruse, Mads Harder Møller, Blanca López-Méndez, Yuqing Zhang, Yujing Zhai, Ying Wang, Tingting Lei, Arminja N. Kettenbach, Jakob Nilsson, Gang Zhang   +11 more
doaj   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source