Results 111 to 120 of about 9,921 (221)
Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley +1 more source
, 2014 A) Plk1 has a modular domain structure with an N-terminal kinase domain and two C-terminal polo box motifs that make the polo-box domain (PBD). B) 3D co-crystal structure of the Plk1-PBD-ligand complex (PDB ID: 3P34). The Plk1-PBD and ligand are shown in
Jorge Z. Torres (600803) +4 more
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
, 2012 A Western blot of immunoprecipitates (IP) or lysates (Lys) from HEK293T cells co-transfected with plasmids expressing V5-tagged NPHP1 and Flag-tagged Plk1 or negative control protein (Eps1–225 [13]). β-actin was assessed as a loading control.
Tamina Seeger-Nukpezah (159345) +6 more
core +1 more source
International Journal of Genomics, 2014 Polo-like kinase 1 (PLK1), one of serine/threonine-protein kinase, has been demonstrated to play pivotal roles in malignant transformation. Here we illustrated the clinicopathological significance of PLK1 expression in hepatocellular carcinoma (HCC) in ...
Wei Sun +6 more
doaj +1 more source
Phytotherapy Research, EarlyView.Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan +8 more
wiley +1 more source
The Plk1 Piece of the Nuclear Envelope Disassembly Puzzle [PDF]
Developmental Cell, 2017 Reporting in this issue of Developmental Cell, Linder et al. (2017) and Martino et al. (2017) reveal in highly complementary studies that Plk1 is recruited to the nuclear pore complex upon mitotic entry, where it acts with Cdk1 to hyperphosphorylate nucleoporin interfaces to promote NPC disassembly and nuclear envelope breakdown.
T Renee, Dawson, Susan R, Wente
openaire +2 more sources
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
, 2012 (A) Total cell lysates (TCL) from cells expressing Axin or Axin2 with PLK1 or empty vector in HEK293T cells were analyzed by immunoblotting as indicated. (B) Axin interacts with PLK1 at its endogenous level.
Yih-Cherng Liou (28603) +5 more
core +1 more source
UBAP2L-dependent coupling of PLK1 localization and stability during mitosis
, 2022 PLK1 is a key regulator of mitosis whose protein levels and activity fluctuate during cell cycle. PLK1 dynamically localizes to distinct mitotic structures to regulate proper chromosome segregation.
Vuidel, Aurore +6 more
core +1 more source