Results 121 to 130 of about 9,921 (221)

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

EBioMedicine, 2019
Background Targeting PLK1 has recently been proven as a viable therapeutic strategy against oesophageal squamous cell carcinom (ESCC). Therefore, this study aimed to explore whether the PLK1 inhibitor BI2536 is able to sensitize ESCC cells to cisplatin ...
Meng-Jiao Wu, Yan Wang, Di Yang, Ying Gong, Feng Rao, R. Liu, Yeerken Danna, Jinting Li, Jia-Wen Fan, Jie Chen, Wei-Min Zhang, Q. Zhan   +11 more
semanticscholar   +1 more source

Non‐canonical cMet regulation by vimentin mediates Plk1 inhibitor–induced apoptosis

EMBO Molecular Medicine, 2019
To address the need for improved systemic therapy for non–small‐cell lung cancer (NSCLC), we previously demonstrated that mesenchymal NSCLC was sensitive to polo‐like kinase (Plk1) inhibitors, but the mechanisms of resistance in epithelial NSCLC remain ...
Ratnakar Singh, Shaohua Peng, Pavitra Viswanath, Vaishnavi Sambandam, Li Shen, Xiayu Rao, Bingliang Fang, Jing Wang, Faye M Johnson   +8 more
doaj   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Re-investigating PLK1 inhibitors as antimitotic agents

, 2017
Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently determined that PLK1 is crucially required for entry into mitosis.
Delacour, Quentin, Gavet, Olivier, Quentin Delacour, Olivier Gavet   +3 more
core   +1 more source

Clinical relevance of PLK1 in epithelial ovarian cancer

Frontiers in Pharmacology
Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the most aggressive and lethal gynecologic malignancy, necessitating the development of innovative and potent therapies to improve its prognosis.
Xiaochang Shen, Xiaochang Shen, Jiandong Wang, Shuning Chen, Shuning Chen, Haomeng Zhang, Haomeng Zhang, Chunxiao Zhou, Chunxiao Zhou, Victoria L. Bae-Jump, Victoria L. Bae-Jump   +10 more
doaj   +1 more source

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

Functional and structural impacts of oncogenic missense variants on human polo-like kinase 1 protein

Frontiers in Bioinformatics
IntroductionThe polo-like kinase 1 (PLK1), a master key mitotic regulator, is frequently expressed in various types of cancers and associated with poor prognosis.
Gayatri Munieswaran, Venkatraman Manickam   +1 more
doaj   +1 more source

Identifying Co‐Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Nutrigenomics investigates how nutrients modulate gene expression. Among them, fatty acids (FA) play important roles in regulating gene transcription, while long non‐coding RNAs (lncRNAs) may be associated with gene regulation and metabolic diseases.
Lucas Echevarria Nascimento, Bruna Pereira Martins da Silva, Camila Sabino de Oliveira, Mariah Castro Durval, Felipe André Oliveira Freitas, Fernanda Nery Ciconello, Izally Carvalho Gervásio, Simara Larissa Fanalli, Pablo Augusto de Souza Fonseca, Beatriz Gutiérrez‐Gil, Vivian Vezzoni de Almeida, Aline Silva Mello Cesar   +11 more
wiley   +1 more source

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. [PDF]

, 2015
Polyploidization in megakaryocytes is achieved by endomitosis, a specialized cell cycle in which DNA replication is followed by aberrant mitosis. Typical mitotic regulators such as Aurora kinases or Cdk1 are dispensable for megakaryocyte maturation, and ...
Trakala, Marianna, Wachowicz, Paulina, Maroto, María, de Carcer Diez, Guillermo, Partida, David, Salazar-Roa, Maria, Malumbres Martinez, Marcos, Malumbres, Marcos, Carcer, Guillermo de, Salazar Roa, María   +9 more
core   +1 more source

Immunoinformatic-guided design of a polo-like kinase 1 (PLK1)-targeted multi-epitope vaccine with preliminary in vitro validation

Frontiers in Bioinformatics
IntroductionPolo-like kinase 1 (PLK1) is a well-established oncogenic protein, as indicated by elevated levels of protein expression and function in a variety of tumor malignancies, and thus helps in metastasis of the disease.
Gayatri Munieswaran, Nandha Kumar Subramani, Anand Prem Rajan, Venkatraman Manickam   +3 more
doaj   +1 more source