Results 131 to 140 of about 9,921 (221)

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

Nature Communications, 2020
A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC) develop resistance to endocrine treatments (ET) and relapse with metastatic disease.
E. Montaudon, J. Nikitorowicz-Buniak, L. Sourd, L. Morisset, R. El Botty, L. Huguet, A. Dahmani, P. Painsec, F. Némati, S. Vacher, W. Chemlali, J. Masliah-Planchon, S. Chateau-Joubert, Camilla Rega, M. Leal, Nikiana Simigdala, S. Pancholi, Ricardo Ribas, A. Nicolas, D. Meseure, A. Vincent-Salomon, C. Reyes, Audrey Rapinat, D. Gentien, T. Larcher, M. Bohec, S. Baulande, V. Bernard, D. Decaudin, F. Coussy, M. Le Romancer, G. Dutertre, Zakia Tariq, P. Cottu, K. Driouch, I. Bièche, L. Martin, E. Marangoni   +37 more
semanticscholar   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, Volume 13, Issue 51, 14 September 2026.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, Volume 13, Issue 51, 14 September 2026.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Polo-like Kinase 1 Predicts Lymph Node Metastasis in Middle Eastern Colorectal Cancer Patients; Its Inhibition Reverses 5-Fu Resistance in Colorectal Cancer Cells

Cells
Polo-like kinase 1 (PLK1) is a serine/threonine–protein kinase essential for regulating multiple stages of cell cycle progression in mammals. Aberrant regulation of PLK1 has been observed in numerous human cancers and is linked to poor prognoses. However,
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Khadija Alobaisi, Saravanan Thangavel, Rafia Begum, Roxanne Diaz, Fouad Al-Dayel, Khawla S. Al-Kuraya   +9 more
doaj   +1 more source

The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation.

PLoS ONE, 2016
Mitosis is coordinated by carefully controlled phosphorylation and ubiquitin-mediated proteolysis. Polo-like kinase 1 (Plk1) plays a central role in regulating mitosis and cytokinesis by phosphorylating target proteins.
Amber L Lasek, Brittany M McPherson, Natalie G Trueman, Mark E Burkard   +3 more
doaj   +1 more source

Next‐Generation Pluronic Micelles for Advanced Drug Delivery Application

Macromolecular Materials and Engineering, Volume 311, Issue 9, September 2026.
The present review provides a comprehensive overview of Pluronic‐based micelles for advanced drug and gene delivery. It highlights their structure, classification, synthesis, self‐assembly, and functionalization, as well as their biocompatibility and stimuli‐responsive properties.
Manoj Gundeti, Nithin Vidiyala, Shreya Dalvi, Rushikesh Girase, Sunil kumar Thota, Keshav Raj Paudel, Sathish Dyawanapelly   +6 more
wiley   +1 more source

Gravin regulates centrosome function through PLK1

, 2018
We propose to understand how the mitotic kinase PLK1 drives chromosome segregation errors, with a specific focus on Gravin, a PLK1 scaffold. In both three-dimensional primary prostate cancer cell cultures that are prone to Gravin depletion and Gravin ...
Peu Santra, Alice M. Garrastegui, Heidi Hehnly, Dawn E. Post, Judy Freshour, Erica G. Colicino, Leszek Kotula   +6 more
core   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source