Results 151 to 160 of about 9,921 (221)

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration

eLife, 2019
Muscle development and regeneration require delicate cell cycle regulation of embryonic myoblasts and adult muscle satellite cells (MuSCs). Through analysis of the Polo-like kinase (Plk) family cell-cycle regulators in mice, we show that Plk1’s ...
Zhihao Jia, Yaohui Nie, Feng Yue, Yifan Kong, Lijie Gu, Timothy P Gavin, Xiaoqi Liu, Shihuan Kuang   +7 more
doaj   +1 more source

Co-delivery of doxorubicin and recombinant plasmid pHSP70-Plk1-shRNA by bacterial magnetosomes for osteosarcoma therapy

, 2016
Li Cheng, Youqun Ke, Shuisheng Yu, Juehua Jing Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, People’s Republic of China Abstract: To explore a novel combination of ...
Ke Y, Jing J, Yu S, Cheng L
core  

Polo-like kinase 1 inhibits the activity of positive transcription elongation factor of RNA Pol II b (P-TEFb).

PLoS ONE, 2013
Polo-like kinase 1 (Plk1) is a highly conserved Ser/Thr kinase in eukaryotes and plays a critical role in various aspects of the cell cycle. Plk1 exerts its multiple functions by phosphorylating its substrates.
Liangzhen Jiang, Yan Huang, Min Deng, Ting Liu, Wenbin Lai, Xin Ye   +5 more
doaj   +1 more source

Deciphering the Dysregulated Pathways and Candidate Therapeutic Compounds for Primary Ovarian Cancer Using Whole Transcriptomics Data and Next Generation Knowledge Discovery Strategies

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Ovarian cancer (OC) is a type of gynaecological cancer with a higher mortality rate due to diagnosis at an advanced stage and limited treatment options. This study aimed to leverage transcriptomic data to identify cellular and molecular pathways and potential anti‐cancer compounds that specifically target primary invasive epithelial ovarian ...
Peter Natesan Pushparaj, Kalamegam Gauthaman, Alaa G. Alahmadi, Reem Nabil Hassan, Hind A. Alkhatabi, Ammar AL‐Farga   +5 more
wiley   +1 more source

Cell Cycle: On-Time Delivery of Plk1 during Cytokinesis [PDF]

, 2007
At anaphase, the kinase Plk1 localizes to the spindle midzone, where it orchestrates cytokinesis. New work has now identified PRC1 as a Plk1-delivery factor that is tightly controlled by opposing cyclin B–Cdk1- and Plk1-dependent ...
Rape, Michael
core   +1 more source

Comparative Response of Canine and Human Osteosarcoma Tumour Cell Lines to Molecularly Targeted Anticancer Agents at Clinically Relevant Exposures With Analysis of Genomic Biomarkers

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 532-544, September 2026.
ABSTRACT Osteosarcoma (OSA) is a primary bone tumour occurring in children but is also prevalent in large breed dogs. Canine OSA (cOSA) has long been viewed as analogous to human OSA (hOSA) with cOSA serving as a surrogate for development of therapeutic approaches to treat the rarer human form.
Daniel L. Gustafson, Kala A. Early, Maritza A. Morales, Klaudia A. Poplawski, Sunetra Das, Dawn L. Duval   +5 more
wiley   +1 more source

PLK1 phosphorylates WRN at replication forks

The Journal of Pharmacology and Experimental Therapeutics
Prostate cancer, particularly castration-resistant prostate cancer, remains a serious public health issue. Androgen signaling inhibitors have emerged as a major treatment approach but with limited success. Thus, identification of novel treatment targets is of high clinical relevance.
Lei Wang, Daheng He, Qianjin Li, David Orren, Chi Wang, Jinpeng Liu, Zhiguo Li, Xiaoqi Liu   +7 more
openaire   +3 more sources

Effect of adenovirus-delivered Plk1 on HeLa cell number and Plk1 activity.

, 2013
Plk1 enhanced cell division in HeLa cells at 48 hours post infection (A and B). The activity of adenovirus-delivered Plk1 was assessed in P10 cardiac myocytes (C).
Gavin Brooks (370915), Fleur L. Moseley (370914), Katrina A. Bicknell (370912), Carmen H. Coxon (298171)   +3 more
core   +1 more source

Normal Cells, but Not Cancer Cells, Survive Severe Plk1 Depletion

, 2019
We previously reported the phenotype of depletion of polo-like kinase 1 (Plk1) using RNA interference (RNAi) and showed that p53 is stabilized in Plk1-depleted cancer cells.
Liu, Xiaoqi, Erikson, Raymond L., Lei, Ming   +2 more
core   +1 more source