Results 161 to 170 of about 9,921 (221)

Polo-like Kinase 1 Activation Regulates Angiotensin II-Induced Contraction in Pudendal and Small Mesenteric Arteries from Mice

Cells
Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase expressed in smooth muscle cells (SMCs), with emerging roles in regulating contraction. We hypothesize that PLK1 contributes to smooth muscle contractility in pudendal arteries (PA), small ...
Raiana Anjos Moraes, Olufunke O. Arishe, James Pratt, Stephanie Wilczynski, Rinaldo Rodrigues dos Passos, Diana L. Silva-Velasco, Tiago Tomazini Gonçalves, Tianxin Zhang, Darizy Flavia Silva, R. Clinton Webb, Fernanda Priviero   +10 more
doaj   +1 more source

Identification of PLK1 phosphorylation sites on Axin.

, 2012
(A) Mass spectrometry analysis using Axin immunoprecipitates shows that Ser-157 in Axin is one of the phosphorylation sites of PLK1. Upper panel: HA-Axin was immunoprecipitated from cells co-expressing PLK1-WT; lower panel: from cells co-expressing PLK1 ...
Yih-Cherng Liou (28603), Ka Ruan (120594), Fan Ye (120597), Chenyu Li (120599), Shu-Yong Lin (120603), Sheng-Cai Lin (120601)   +5 more
core   +1 more source

PLK1 Mediates the Proliferation and Contraction of Airway Smooth Muscle Cells and Has a Role in T2-High Asthma with Neutrophilic Inflammation Model

Journal of Inflammation Research
Yilin Pan,1,* Yishu Xue,1,* Xia Fei,1,* Lei Zhao,1,* Lei Han,1 Hang Su,1 Yanmei Lin,1 Yan Zhou,1 Yingying Zhang,1 Guogang Xie,1 Deping Kong,2 Wuping Bao,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General ...
Pan Y, Xue Y, Fei X, Zhao L, Han L, Su H, Lin Y, Zhou Y, Zhang Y, Xie G, Kong D, Bao W, Zhang M   +12 more
doaj  

Plk1-dependent substrates.

, 2013
(a) Cell-cycle diagram depicting proteins sorted out through sequence based approach having Plk1 phosphorylation motif. Proteins are classified according to function and localization.
Nousheen Bibi (446289), Zahida Parveen (446290), Sajid Rashid (277111)   +2 more
core   +1 more source

Bora, CEP192 and Cenexin regulate distinct Plk1-dependent cell and centrosome cycle transitions

Nature Communications
Polo-like kinase 1 (Plk1) regulates multiple steps of the cell and centrosome cycle, including mitotic entry, DNA-damage recovery, centrosome maturation and centriole disengagement.
Devashish Dwivedi, Crisálida Borges, Daniela Harry, Luca Cirillo, Patrick Meraldi   +4 more
doaj   +1 more source

Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells

Frontiers in Oncology
Novel therapeutic approaches are needed for the treatment of Ewing sarcoma tumors. We previously identified that Ewing sarcoma cell lines are sensitive to drugs that inhibit protein translation.
Joseph A. Haight, Stacia L. Koppenhafer, Elizabeth L. Geary, David J. Gordon   +3 more
doaj   +1 more source

Treacle interacts with PLK1 and mediates its localization.

, 2012
(A) Immunofluorescent localization of Treacle (green) and PLK1 (red) in mitotic HeLa cells. (B) Interaction between FLAG-tagged Treacle and HA-tagged Plk1 as evidenced by immunoprecipitation (IP) using an anti-FLAG antibody. Precipitated Plk1 and Treacle
Paul A. Trainor (129368), Michael J. Dixon (174991), Jill Dixon (174981), Daisuke Sakai (174973)   +3 more
core   +1 more source

Assessing the toxicological effects of exposure to polyethylene terephthalate on hepatocellular carcinoma: insights from network toxicology, molecular docking, molecular dynamics, and experimental validation

Frontiers in Pharmacology
BackgroundPolyethylene terephthalate (PET), one of the most widely used synthetic polymers globally, has emerged as a potential environmental risk factor for human health. However, the molecular mechanisms linking PET exposure to hepatocellular carcinoma
Peng Chen, Xin Liu, Dongmei Yuan, Lan Zheng, Yumin Du, Dacai Gong, Xing Wei, Dan Wang, Ge Xu, Bin Ge   +9 more
doaj   +1 more source

Plk1 represses P-TEFb-dependent transcription.

, 2013
(A) Schematic map of G5-83-HIV-Luc reporter. (B) 293T cells were co-transfected with Plk1, Plk1 TD or Plk1 KD expression plasmids and HIV-1 LTR luciferase reporter for 36 h. The cell lysates were harvested for luciferase assay.
Ting Liu (45625), Liangzhen Jiang (446973), Yan Huang (46805), Min Deng (114029), Wenbin Lai (446974), Xin Ye (208347)   +5 more
core   +1 more source

Plk1 in DNA replication: Implication for chemoresistance

, 2012
Two critical steps during eukaryotic cell proliferation are duplication of the genome in S phase and separation of the duplicated genome into two daughter cells in mitosis. Tight regulation of the cell cycle is vital in order to maintain genome stability
Song, Bing
core   +1 more source