Results 171 to 180 of about 9,921 (221)

PLK1/FOXM1-associated tumor-cell state and macrophage-related immune features in endometrial cancer

Frontiers in Oncology
BackgroundPolo-like kinase 1 (PLK1) and forkhead box M1 (FOXM1) have been widely studied in various cancers; however, their expression characteristics in endometrial cancer (EC) and their potential association with tumor microenvironment remodeling ...
Longwei Li, Longwei Li, Yunyun Xiao, Yunyun Xiao, Yaping Wang, Guangyao Song, Ming Liu, Xueling Qu, Lu Han   +8 more
doaj   +1 more source

KIF2A Upregulates PI3K/AKT Signaling through Polo-like Kinase 1 (PLK1) to Affect the Proliferation and Apoptosis Levels of Eriocheir sinensis Spermatogenic Cells

Biology
E. sinensis is an animal model for studying the reproduction and development of crustaceans. In this study, we knocked down the Es-Kif2a gene by injecting dsRNA into E.
Yan-Shuang Zhao, Ding-Xi Liu, Fu-Qing Tan, Wan-Xi Yang   +3 more
doaj   +1 more source

Multiple requirements of PLK1 during mouse oocyte maturation.

, 2015
Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division. Although PLK1 function has been intensively studied in centriole-containing and rapidly cycling somatic cells, much less is known about its function in the meiotic divisions of ...
Shuhei Yoshida, Alexandra Mayer, Tomoya S Kitajima, Petr Solc (690451), Jan Motlik (334413), Jan Motlik, Pavlina Samalova (690458), Alexandra Mayer (690457), Adela Brzakova, Shuhei Yoshida (690453), Vladimir Baran (690456), Jan Ellenberg (114572), Jan Ellenberg, Tomoya S. Kitajima (690452), Masako Kaido, Vladimir Baran, Adela Brzakova (690454), Pavlina Samalova, Petr Solc, Masako Kaido (690455)   +19 more
core   +1 more source

Nitidine chloride suppresses polo-like kinase 1 via MYCN-associated transcriptional regulation in colorectal cancer: a multi-omics and spatial transcriptomics study

Frontiers in Oncology
BackgroundColorectal cancer (CRC) remains a major global health burden. While nitidine chloride (NC) exhibits anti-tumor effects, its molecular targets in CRC are still largely unknown.MethodsTo delineate the role of Polo-like kinase 1 (PLK1) in CRC, we ...
Xiao-Jue Huang, Xiao-Jue Huang, Liu-Hui Mo, Liu-Hui Mo, Ke-Jun Wu, Rong-Quan He, Hui Li, Gang Chen, Li-Min Liu   +8 more
doaj   +1 more source

Localization of sorcin and PLK1 within the midbody and in vitro PLK1 kinase assay.

, 2014
A: Cells in cytokinesis were stained for sorcin and PLK1. Observe sorcin accumulation on both sides of PLK1 (white arrows). B: Cos7 cells expressing GFP-sorcin were stained for PLK1. Bars 10 µm.
Elena Poser (508327), David J. O'Connell (508326), Vasiliki S. Lalioti (508325), Andrea Ilari (140699), Gianni Colotti (140696), Ignacio V. Sandoval (508328)   +5 more
core   +1 more source

Lipid Encapsulated Anti-PLK1 siRNA TKM-PLK1 [PDF]

, 2020
openaire   +1 more source

Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway

Cellular Signalling
Lung adenocarcinoma (LUAD), responsible for nearly half of lung cancer cases, is one of the most prevalent and lethal malignant tumors globally. There is increasing evidence suggesting that the oncoprotein PLK1 plays a role in the onset and advancement of different types of cancer, including LUAD.
Ran, Liu, Dafa, Zhou, Bentong, Yu, Zizhang, Zhou   +3 more
openaire   +2 more sources

PLK1 Gene [PDF]

, 2020
openaire   +1 more source

Pharmacological inhibition of PLK1/PRC1 triggers mitotic catastrophe and sensitizes lung cancers to chemotherapy

Cell Death and Disease
Polo-like kinase 1 (PLK1) signaling drives tumor malignancy and chemotherapy resistance, which is an unmet clinical need. Recruiting PLK1 to the central spindle during anaphase is necessary for its function in promoting cancer cell proliferation, which ...
Pingping Li, Yufei Zhao, Minghan Lu, Chengfei Chen, Yongkun Li, Lingling Wang, Shulan Zeng, Yan Peng, Hong Liang, Guohai Zhang   +9 more
doaj   +1 more source

PLK1 wt Allele [PDF]

, 2020
openaire   +1 more source