Results 191 to 200 of about 9,921 (221)

Molecular dynamics of PLK1 during mitosis [PDF]

Molecular and Cellular Oncology, 2014
Polo-like kinase 1 (PLK1) is a key regulator of eukaryotic cell division. During mitosis, dynamic regulation of PLK1 is crucial for its roles in centrosome maturation, spindle assembly, microtubule-kinetochore attachment, and cytokinesis. Similar to other members of the PLK family, the molecular architecture of PLK1 protein is characterized by 2 ...
Izabela Sumara
exaly   +4 more sources

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Plk1 is negatively regulated by RNF8

Biochemical and Biophysical Research Communications, 2011
RNF8 is a nuclear protein having an N-terminal forkhead-associated (FHA) domain and a C-terminal RING-finger (RF) domain. Depletion of RNF8 caused cell growth inhibition and cell cycle arrest at not only S but also G2/M phases. In addition, cell death was frequently observed in RNF8-depleted cells.
Takashi, Yoshioka, Masashi, Kimura, Masanao, Saio, Seiichi, Era, Yukio, Okano   +4 more
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Cullin' PLK1 from kinetochores

Nature Cell Biology, 2013
To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin. The monoubiquitylation of PLK1 by the ubiquitin ligase CUL3-KLHL22 is now identified as a critical step in promoting the release of PLK1 from ...
Colleen A, McGourty, Michael, Rape
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PLK1 promotes cholesterol efflux and alleviates atherosclerosis by up-regulating ABCA1 and ABCG1 expression via the AMPK/PPARγ/LXRα pathway.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2022
Polo-like kinase 1 (PLK1) is a serine/threonine kinase involving lipid metabolism and cardiovascular disease. However, its role in atherogenesis has yet to be determined.
Heng-Jing Hu, Xiu-Ying Wang, Tian-Qing Zhang, Yao Liu, Zheng-Rong Chen, Zhi-Zhu Zhang, Hongfang Huang, Hui Tang, Zhi-Sheng Jiang   +8 more
semanticscholar   +1 more source

Chfr Ubiquitinates Plk1

Science Signaling, 2002
Controlled degradation is in large measure the driving force that directs the cell cycle forward. Two ubiquitin ligases known to act during cell-cycle progression are the Skp1/cullin/F-box (SCF) ligase that controls the G1-to-S transition and the anaphase-promoting complex (APC) that controls exit from mitosis. Kang et al
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Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis

Inflammation Research, 2023
Yuntao Liu, Yuting Zhang, Guoxing You, D. Zheng, Zhipeng He, Wenjie Guo, Kim Antonina, Ziyadullaev Shukhrat, Bang-Han Ding, Jie Zan, Zhongde Zhang   +10 more
semanticscholar   +1 more source

Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase

Nature Nanotechnology, 2021
X. Shao, Z. Ding, Wenhua Zhou, Yan-Yan Li, Zhi-Bin Li, Hao-Dong Cui, Xian Lin, Guoli Cao, Binghua Cheng, Haiyan Sun, Meiqing Li, Ke Liu, Danyi Lu, Sheng-Yong Geng, Wenli Shi, Guofang Zhang, Qing-Le Song, Liang Chen, Guocheng Wang, Wu Su, Lintao Cai, Li-Jing Fang, D. Leong, Yang Li, Xue-Feng Yu, Hongchang Li   +25 more
semanticscholar   +1 more source

PLK1 inhibition-based combination therapies for cancer management

Translational Oncology, 2022
Gagan Chhabra, Nihal Ahmad, Mary Ndiaye   +2 more
exaly  

Selectivity-determining residues in Plk1.

Chemical biology & drug design, 2008
Polo-like kinase 1 is an important regulator of cell cycle progression whose over-expression is often associated with oncogenesis. Polo-like kinase 1 hence represents an attractive target for cancer intervention. BI 2536 (Boehringer Ingelheim, Ingelheim, Germany), a Polo-like kinase 1 inhibitor currently in clinical trials, exhibits nanomolar potency ...
Michael, Kothe, Darcy, Kohls, Simon, Low, Rocco, Coli, Glen R, Rennie, Frederic, Feru, Cyrille, Kuhn, Yuan-Hua, Ding   +7 more
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Pyrrole derivatives as PLK1 inhibitors

2021
BOYLE ROBERT GEORGE, WALKER DAVID WINTER, BOYCE RICHARD JUSTIN   +2 more
openaire   +3 more sources