Results 181 to 190 of about 9,921 (221)
Plk1 in Asthma: Ready for Primetime?
American Journal of Respiratory Cell and Molecular Biology, 2022 Tam, John Kit Chung, Tran, Thai
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Chk2 Sustains Mitotic PLK1 Activity to Promote Proper Chromosome Segregation
Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division, and its activity is tightly regulated throughout the cell cycle.
Black, Elizabeth Maureen
core
Targeting Plk1 for cancer therapy
European Journal of Cancer Supplements, 2006 Schmidt, Mathias +4 more
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Plk1 is negatively regulated by RNF8
Plk1 is negatively regulated by RNF8博士論文 (Doctoral dissertation)
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PLK1 inhibition impairs erythroid differentiation [PDF]
Frontiers in Cell and Developmental BiologyPolo-like kinase 1 (PLK1), a key regulator of the G2/M phase in mitosis, is frequently overexpressed in numerous tumors. Although PLK1 inhibitors have emerged as promising therapeutic agents for cancer, their use has been linked to significant anemia in a subset of patients, yet the underlying mechanisms remain poorly understood.
Peijun Jia +11 more
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PLK1 Activation in Late G2 Sets Up Commitment to Mitosis
Cell Reports, 2017 Commitment to mitosis must be tightly coordinated with DNA replication to preserve genome integrity. While we have previously established that the timely activation of CyclinB1-Cdk1 in late G2 triggers mitotic entry, the upstream regulatory mechanisms ...
Bérangère Lombard +2 more
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