Results 51 to 60 of about 6,609,888 (231)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Methodology for assessing the economic potential of border areas and recommendations for its use (on the example of Almaty region)

Экономика: стратегия и практика, 2020
The purpose of the article is to justify the choice of methodology and system of indicators for assessing economic potential adapted to the conditions of rural border areas, as well as, based on the testing of this approach, to rank the border areas of ...
N. K. Nurlanova, A. K. Omarov
doaj  

Rupiah currency strengthening at border area West Kalimantan Province - Gun Tembawang, Suruh Tembawang Village, Entikong District [PDF]

African Journal of Hospitality, Tourism and Leisure, 2019
The use of Malaysian Ringgit in Dusun Gun Tembawang, Suruh Tembawang Village, Entikong District, Sanggau Regency, West Kalimantan Province is very low and there are almost no transactions on Rupiah in this area including tourists use.
Sri Haryaningsih, M.Si, Ira Patriani, M.Si   +1 more
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The Urgency of Border Area Development Towards Special Economic Zones: Legal Guarantees for Social Welfare in Indonesia

Pancasila and Law Review
Border areas will continue to lag behind other regions without proper management. The limited natural resources in these areas pose a challenge for development.
Yahya Ahmad Zein, Arif Rohman
doaj   +1 more source

Authority and Budget for Education Services in the Border Area: Case Study in Sebatik Island, North Kalimantan

Forum Ilmu Sosial, 2020
One of the Indonesia’s land border areas is Sebatik Island, Nunukan Regency, North Borneo Province, which borders on Malaysia. This article aims to examine the gap between the expectation of the improvement of educational services and the reality that ...
Nugroho Trisnu Brata
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source