Results 81 to 90 of about 639,593 (286)

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers. [PDF]

, 2019
Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Gunter, Jeffrey L, Haley, Dana, Jones, David, Kantarci, Kejal, Knopman, David, Kraft, Ruth, Lapid, Maria, Lesnick, Timothy, Rademakers, Rosa, Rosen, Howie, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +22 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Processes underlying rabies virus incursions across US–Canada Border as revealed by whole-genome phylogeography [PDF]

Disease control programs aim to constrain and reduce the spread of infection. Human disease interventions such as wildlife vaccination play a major role in determining the limits of a pathogen’s spatial distribution.
Biek, Roman, Nadin-Davis, Susan A., Real, Leslie A., Trewby, Hannah   +3 more
core   +1 more source

Ears of the Armadillo: Global Health Research and Neglected Diseases in Texas [PDF]

, 2013
Neglected tropical diseases (NTDs) have\ud been recently identified as significant public\ud health problems in Texas and elsewhere in\ud the American South. A one-day forum on the\ud landscape of research and development and\ud the hidden burden of NTDs
AD Harries, AV Bode, BI Restrepo, BI Restrepo, Bruce Y. Lee, BY Lee, BY Lee, C Barona-Vilar, C Bern, C González, CA Petersen, CE Matthews, CL Fredregill, CM Jean, CP McHugh, D Nash, E Dumonteil, EG Radke, EJ Hanford, Harold S. Margolis, HQ Qu, HQ Qu, J Cox, JA Serpa, JC Vazquez-Chagoyan, Jennifer Chow, Jesus G. Valenzuela, JJ Wen, JK Andrus, JK Andrus, JM Brunkard, Jocelyn K. Lambuth, Jon Andrus, Joseph B. McCormick, K Kline, K Purcell, K Schleich, Karen A. Goraleski, KM Lillibridge, KO Murray, KO Murray, KO Murray, Kristy O. Murray, KY Won, LM Gardner, MA Barry, Maria Elena Bottazzi, MM Ramos, MS Nolan, MS Nolan, N Bouri, NA Wright, OA Saldarriaga, P Hotez, P Hotez, P Reiter, Peter J. Hotez, Peter Melby, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, Rebeca Rico-Hesse, RJ Harrigan, S Mirza, S Sarkar, SA Kjos, SP Fisher-Hoch, Susan P. Fisher-Hoch, T Meyer, Y Moolani   +79 more
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Molecular Prevalence, Genetic Diversity, and Tissue Tropism of Bartonella Species in Small Mammals from Yunnan Province, China

Animals
Bartonella is an intracellular parasitic zoonotic pathogen that can infect animals and cause a variety of human diseases. This study investigates Bartonella prevalence in small mammals in Yunnan Province, China, focusing on tissue tropism. A total of 333
Pei-Yu Han, Fen-Hui Xu, Jia-Wei Tian, Jun-Ying Zhao, Ze Yang, Wei Kong, Bo Wang, Li-Jun Guo, Yun-Zhi Zhang   +8 more
doaj   +1 more source

BSE Disease Outbreaks, Structural Change and Market Power in the Canadian Beef Industry [PDF]

This study examines farm to wholesale prices spreads to measure the impact of the Bovine Spongiform Encephalopathy (BSE) disease outbreak on the Canadian beef industry.
Berhanu, Adugna, Cechura, Lukas, Clark, J. Stephen   +2 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source