Results 131 to 140 of about 55,498 (271)

Use of border crops and Coccinellid predators to control the whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), a vector of Begomovirus on chillipepper (Capsicum annuum L.)

, 2012
Whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae) is an important pest on chillipepper due to its role as a vector of Begomovirus, the causal agent of yellow leaf curl disease.
Udiarto, Bagus Kukuh
core  

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Review of Uganda’s high-risk Ebola preparedness activities enabling prompt control of imported Ebola Virus Outbreak from the Democratic Republic of Congo, June 2019

Journal of Interventional Epidemiology and Public Health
Introduction: On 1 August 2018, the Democratic Republic of Congo declared its tenth Ebola Virus Disease (EVD) outbreak in North-Kivu province, 100 km from the Uganda border.
Sandra Nabatanzi, Allan Niyonzima Muruta, Issa Makumbi, Alex Riolexus Ario, Benon Kwesiga, Atek Atwiine Kagirita, Lilian Bulage, Bernard Lubwama, Doreen Nsiimire Gonahasa, Paul Mbaka, Innocent Komakech, Maureen Nabatanzi, Felix Ocom, Jaco Homsy, Vance Brown, Joseph Ojwang, David Matseketse, Ida Marie Ameda, Simon Kyazze, Allan Mpairwe, Julie Harris, Henry Gatyanga Mwebesa, Miriam Nanyunja   +22 more
doaj  

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Koyun pestiviruslarının (Border disease virus, Bovine virus diarrhoea virus) antijenik yakınlıklarının serum nötralizasyon testi ile araştırılması

, 2019
Border Disease (BDV) ve Bovine Virus Diarrhoea (BVDV) virusları, Flaviviridae ailesine ait Pestivirus genusunda bulunan etkenlerdir. Pestiviruslar; koyunlarda abort, ölü doğum, kongenital anomalili veya yaşama gücü zayıf yavru doğumu gibi semptomlarla ...
OĞUZOĞLU, T.Çiğdem (Tez Danışmanı), ERGÜN, Çağlar (Yazar)   +1 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Virus de la diarrhée virale bovine: un virus bovin dans le mouton?

, 2019
Das Bovine Virus Diarrhö Virus (BVD-Virus) und das Border Disease Virus (BD-Virus) sind weltweit verbreitet. Das BVD-Virus befällt hauptsächlich Rinder, BD-Virus vor allem Schafe.
Schweizer, Matthias
core