Results 51 to 60 of about 3,495 (284)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Sistemasi: Jurnal Sistem Informasi, 2018 Jaringan komputer adalah himpunan "interkoneksi" antara dua komputer otonom atau lebih yang terhubung dengan media transmisi kabel (kabel) atau tanpa kabel (nirkabel). Jaringan komputer dalam melakukan komunikasi data antar user.
Akhmad Zulfikar Al Ghivani
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
An Architecture to Manage Incoming Traffic of Inter-Domain Routing Using OpenFlow Networks
Information, 2018 The Border Gateway Protocol (BGP) is the current state-of-the-art inter-domain routing between Autonomous Systems (ASes). Although BGP has different mechanisms to manage outbound traffic in an AS domain, it lacks an efficient tool for inbound traffic ...
Walber José Adriano Silva
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Study of BGP secure scheme based on divide and conquer strategy
Tongxin xuebao, 2012 A new approach was studied for BGP security:SE-BGP.By analyzing the security of SE-BGP,was found it had some secure leaks which couldnt resist active attack.To solve these secure problems of SE-BGP,an AS-alliance-based secure BGP scheme :SA-BGP was ...
Bin WANG +3 more
doaj +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Future InternetThe purpose of this study is to evaluate and compare how well different routing protocols perform in terms of load sharing, link failover, and overall network performance.
Kamal Shahid +2 more
doaj +1 more source