Results 121 to 130 of about 1,864,137 (312)

Quality of the Preschool Education in the Raihat Subdistrict Belu Regency Nusa Tenggara Timur [PDF]

open access: yes, 2015
One form of the basic needs of the Ministry became the responsibility of the Government is the aspect of education, especially basic education. Quality education contributing to the welfare of the community improvement efforts refers to the concept of ...
Neolaka, Melkisedek N.B.C.   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

DISTANCE LEARNING SYSTEM FOR BORDER GUARD AGENCY PERSONNEL IN EUROPEAN UNION MEMBER STATES

open access: yesЗбірник наукових праць Національної академії Державної прикордонної служби України. Серія: педагогічні науки
The article provides a comprehensive analysis of the distance learning system for personnel of border agencies in the European Union. It is established that the professional training of European border guards in a distance format under the auspices of ...
Oleksandra SHEVCHUK
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

PENGGUNAAN TANAH UNTUK RUMAH TINGGAL DI SEMPADAN SUNGAI CODE DALAM KAITANNYA DENGAN PERLINDUNGAN FUNGSI RUANG BERDASARKAN PERATURAN DAERAH NOMOR 2 TAHUN 2010 TENTANG RENCANA TATA RUANG WILAYAH KOTA YOGYAKARTA [PDF]

open access: yes, 2012
This legal writing entitled “The use of land for home living at the border Code River in relation to the protection of the function space based on Regional Regulation Number 2 of 2010 about planalogy in Yogyakarta’ City”, with the problem formulation ...
Prawita, Nita
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

The Area of Freedom, Security and Justice ten years on: Successes and future challenges under the Stockholm Programme. CEPS Paperbacks. June 2010 [PDF]

open access: yes, 2010
This book celebrates the tenth anniversary of the Area of Freedom, Security and Justice (AFSJ) by bringing together the views of key practitioners and policy-makers who have played an outstanding role in thinking about and shaping EU policies on freedom,
Carrera, Sergio   +2 more
core  

Seeing and Thinking Borders

open access: yes, 2015
Accepted manuscript version. Published version at https://www.routledge.com/Borderscaping-Imaginations-and-Practices-of-Border-Making/Brambilla-Laine-Bocchi/p/book/9781472451460.
openaire   +1 more source

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