Results 61 to 70 of about 447,397 (301)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Thinking Through Translation with Theodoros Angelopoulos: Journeys, Border Crossings, Liminality

Respectus Philologicus, 2019
In this paper, I propose to examine the question of journeys, borders, and translation in Theodoros Angelopoulos’ Trilogy of Borders: The Suspended Step of the Stork (1991), Ulysses’ Gaze (1995) and Eternity and a Day (1998), winner of the Palme d’Or at ...
Adriana Şerban
doaj   +1 more source

Home on the border in Ana Castillo's "The Guardians": the colonial matrix of power, epistemic disobedience, and decolonial love [PDF]

, 2017
After 9/11, more than ever in the history of the United States of America, security and domesticity have become paradoxical antonyms in racially and ethnically mixed areas, like that of the US-Mexican border.
Poks, Malgorzata
core  

Building Bridges and Borders with Deficit Thinking [PDF]

Educação & Realidade, 2019
Abstract: In this paper, we look at a high school to college transition program intended to prepare Latinx youth living in Arizona, a southwestern US border state, to negotiate, if not cross, borders, including those associated with accessing college. Purposefully, we problematize the at-risk discourses that reify the nature of these border landscapes ...
Jill Koyama, Suzanne Desjardin
openaire   +6 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The materiality of research: ‘the materiality of facts and fiction: recomposing myself from the sickbed’ by Charlotte Wegener [PDF]

, 2016
In this feature essay, Charlotte Wegener ‘recomposes’ her writing from her sickbed. Drawing inspiration from the work of novelist A.S. Byatt, she describes how dialogue with one of Byatt’s protagonists, Phineas, provides a way of thinking about the ...
Wegener, Charlotte
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The potential of collaborative online international learning as a border thinking third space for global citizenship education

International Journal of Development Education and Global Learning
In this article, we examine the potential of collaborative online international learning as a borderland third space for global citizenship education.
doaj   +2 more sources