Results 71 to 80 of about 231,174 (267)

BALANCING ON THE BORDERLINE OF EARLY AFFECT-CONFUSION - PART 2 OF A CASE STUDY TRILOGY

open access: yesInternational Journal of Integrative Psychotherapy, 2013
Part 2 of a case study trilogy on early affect-confusion describes the psychotherapy relationship between an angry/helpless client and the psychotherapist’s skill in balancing the “borderline” between behavioral management and affect attunement ...
Richard G. Erskine
doaj  

CENTER AND PERIPHERY: BORDERLINE CITIES AND BORDERLINES OF CITIES

open access: yesJournal of Architecture and Urbanism, 2015
„Center and periphery: borderline cities and borderlines of cities" Journal of Architecture and Urbanism, 39(1), p.
openaire   +3 more sources

Borderline Personality Disorder [PDF]

open access: yesCanadian Medical Association Journal, 2005
Abstract Borderline personality disorder (BPD) describes a clinical syndrome commonly seen in practice (Zimmerman, Rothschild, & Chelminski, 2005). The most characteristic symptom is chronic suicidality (Paris, 2002), with recurrent overdoses and selfmutilation.
openaire   +2 more sources

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Tratamiento integral del Trastorno Límite de Personalidad.

open access: yesRevista de la Asociación Española de Neuropsiquiatría, 2010
Los Trastornos de Personalidad (TP) en general y el Trastorno Límite de Personalidad (TLP) en particular, son de difícil abordaje ya que los trastornos de personalidad no están considerados una enfermedad mental como tal al tratarse de patología de eje ...
Raúl Otín Llop   +2 more
doaj  

MIGRENA CRONICĂ LA PACIENȚII ADULȚI ÎN FUNCȚIE DE ATMOSFERA NOCIVĂ DIN FAMILIE ÎN PERIOADA COPILĂRIEI. ROLUL TULBURĂRILOR DE PERSONALITATE

open access: yesBuletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale
Atmosfera nocivă din familie în perioada copilăriei are un impact profund în evoluția migrenei și cronicizarea ei în perioada matură a pacienților.
Ion MOLDOVANU   +4 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Borderline Personality in Patients with Poly-Diagnoses Treated for a Bipolar Disorder

open access: yesMediterranean Journal of Clinical Psychology, 2019
Some patients with dysphoria, explosive behaviour, or suicidal ideation, may receive a diagnosis of, and treatment for Bipolar Disorder (BD) and, not infrequently. The coexistence of these two diagnoses has been explained in different ways.
Laura Ferraro   +8 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

open access: yesFEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa   +4 more
wiley   +1 more source

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