Results 191 to 200 of about 278,522 (247)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

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DEFINITION OF STATE BORDER, BORDER LINE, BORDER BELT, BORDER AREA AND BORDER CROSSING

International Journal of Economics, Management and Tourism, 2022
The history of mankind is known for the emergence of borders between tribes, cultures, civilizations. In the philosophy of the border we know the limitation of all things in time-space, in one territory, with its own power, with its own laws and social order, created through the historical of that society.
Shabani, Erda, Koteski, Cane
openaire   +1 more source

The Border and the Bordered

2004
The parish of Gryt in central Sodermanland, Sweden, constitutes the area of investigation in an ongoing research project The Parish Gryt — Landscape and Community in an Ecosystem Perspective (Figure 1). An ecosystem approach is being employed in this study, in order to analyse the parish community’s ecological relation with its territory over time. the
Maria Bergström, Margareta Ihse
openaire   +1 more source

Borders and Bordering

European Journal of Social Theory, 2006
The renaissance of border studies during the past decade has been characterized by a crossing of disciplinary borders, bringing together geographers, political scientists, sociologists, anthropologists, historians, literary scholars, legal experts, along with border practitioners engaged in the practical ...
openaire   +1 more source

Prologue: A Border is Not a Border. Writing and Reading Borders in Space

2018
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Berg, E. van den, Houtum, H.J. van
openaire   +2 more sources

Introduction: The Border Is Not at the Border

2020
A visible or invisible dividing line, the border is usually perceived in terms of separation and rupture, but it is also a principle of organization of international relations. It is therefore a site of tension with regard to identity construction and assertion; the border is often at the very origin of contestations, negotiations, and other ...
Myriam Moïse, Fred Réno
openaire   +1 more source

Borders and Bordering

Summary Borders are dynamic systems that classify, control, and distribute rights, resources, and mobility. In sociological terms, they function as institutions that help organize global inequality by determining who may move, under what conditions, and with what consequences.
openaire   +2 more sources