Results 201 to 210 of about 244,820 (268)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH) syndrome treated with upadacitinib. [PDF]

JAAD Case Rep
Javaheri E, Chen SX.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Somalia's Drought-Disease Spiral: Climate Shocks as an Emerging Public Health Security Threat. [PDF]

Risk Manag Healthc Policy
Abdi AM, Mohamud OM, Iman MI, Osman NH, Jimale AM, Adam AA, Mohamud MA, Ali MA.   +7 more
europepmc   +1 more source

Paraxanthine and azilsartan attenuate gentamicin-induced renal fibrosis via modulation of TGF-β1/Smad3/7 signaling and miRNA-21/miRNA-200b expression. [PDF]

J Transl Med
Rizk El-Adwy NS, El-Ashmawy NE, Al-Ashmawy GM, Khedr NF.   +3 more
europepmc   +1 more source

Ocular multimodal imaging of a patient with malignant atrophic papulosis (Degos disease). [PDF]

Am J Ophthalmol Case Rep
Barbé A, El Maamar Y, Farhat MM, Launay D, Hachulla É, Ledoult E.   +5 more
europepmc   +1 more source

Gardner syndrome initially misdiagnosed as bilateral breast malignancy: a case report and literature review. [PDF]

Front Oncol
Qian R, Zhang G, Liu J, Kong W.
europepmc   +1 more source

Splenic B-Cell Lymphoma/Leukemia With Prominent Nucleoli Presenting With Characteristic Peripheral Blood and Bone Marrow Findings. [PDF]

EJHaem
Son K, Shimomura Y, Yamashita D, Kondo T.   +3 more
europepmc   +1 more source