Results 21 to 30 of about 338 (149)
Angewandte Chemie, Volume 134, Issue 46, November 14, 2022., 2022 Using a fragment‐based screening strategy by NMR, we identified 311 small molecule binders of 25 SARS‐CoV‐2 proteins, thus expanding the previously unexplored chemical and target space. Further, using experimental and bioinformatic analysis we identify potential binding sites.
Hannes Berg +82 more
wiley +2 more sources
Bausteine zu einer Oral History der Wissenschaftsgeschichte Interview mit Dieter Hoffmann
Berichte zur Wissenschaftsgeschichte, Volume 46, Issue 4, Page 378-412, December 2023., 2023 Abstract Wie kann man einen historischen Blick auf das eigene Fach werfen? Diese Frage ist nicht einfach zu beantworten – will man einerseits nicht in einer Nabelschau und Hagiographie enden, andererseits aber auch keinen umfassenden Entwurf einer zukünftigen Historiographie vorlegen.
Mathias Grote +2 more
wiley +1 more source
Chemistry – A European Journal, Volume 29, Issue 25, May 2, 2023., 2023 A library of post‐transcriptional modifications and synthetic modified nucleosides for the site‐specific alteration of RNAs applying a chemo‐enzymatic method is presented. This method overcomes the limitations of other established and well‐known RNA synthesis techniques.
Alexey Sudakov +5 more
wiley +1 more source
Angewandte Chemie, Volume 135, Issue 14, March 27, 2023., 2023 Dieser Viewpoint Article beschreibt die Selbstorganisation der weltweiten NMR‐Gemeinschaft, um einen zeitnahen Beitrag zur Bekämpfung von SARS‐CoV‐2 zu leisten. Diese neue Art der kollaborativen Forschung könnte als Modell für die Bewältigung weiterer aktueller und künftiger großer gesellschaftlicher Bedürfnisse dienen, ohne dabei mit ...
Elke Duchardt‐Ferner +10 more
wiley +1 more source
The COVID19‐NMR Consortium: A Public Report on the Impact of this New Global Collaboration
Angewandte Chemie International Edition, Volume 62, Issue 14, March 27, 2023., 2023 This Viewpoint Article discusses how the global NMR community organized itself to rapidly contribute to combat SARS‐CoV‐2. This new collaborative research might serve as model for future ways to address great societal needs, without competing with curiosity‐driven research.
Elke Duchardt‐Ferner +10 more
wiley +1 more source
El lugar de Boris Hessen en la polémica soviética entre mecanicistas y dialécticos
, 1998 Es un capítulo del libro de Pablo Huerga, La ciencia en la encrucijada, Pentalfa eds., Oviedo 1999. El artículo incluye al final el índice completo del libro.
Huerga Melcón, Pablo
openaire +2 more sources
EETTlib—Energy‐efficient train timetabling library
Networks, Volume 81, Issue 1, Page 51-74, January 2023., 2023 Abstract We introduce EETTlib, an instance library for the Energy‐Efficient Train Timetabling problem. The task in this problem is to adjust a given timetable draft such that the energy consumption of the resulting railway traffic is minimized. To this end, the departure times of the trains can be slightly, and their velocity profiles on each trip can ...
Andreas Bärmann +4 more
wiley +1 more source
Glia, Volume 70, Issue 5, Page 842-857, May 2022., 2022 Main Points Astrocytes are effective target cells for gene therapy against amyotrophic lateral sclerosis. SOD1‐targeting gene therapy in astrocytes protects fast‐fatigable motor units. RNAi gene therapy directed to astrocytes induces motoneuron plasticity.
Cylia Rochat +7 more
wiley +1 more source
Boris Hessen and Newton's God [PDF]
, 2019 A significant thread in Boris Hessen‟s iconic essay, The Social and Economic Roots of Newton’s Principia (1931), is his critique of Newton‟s involving God in his physics.
Trisokkas, Ioannis
core +1 more source