Results 191 to 200 of about 30,156 (257)
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Enabling Reductive C-N Cross-Coupling of Nitroalkanes and Boronic Acids by Steric Design of P(III)/P(V)═O Catalysts. [PDF]
J Am Chem Soc, 2022 Li G, Kanda Y, Hong SY, Radosevich AT.
europepmc +1 more source
Advanced Science, EarlyView.A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang +11 more
wiley +1 more source
Synthesis of aryldifluoromethyl aryl ethers via nickel-catalyzed suzuki cross-coupling between aryloxydifluoromethyl bromides and boronic acids. [PDF]
Commun Chem, 2022 Lu H +5 more
europepmc +1 more source
Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics
Advanced Science, EarlyView.. ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao +3 more
wiley +1 more source
Rhodium(I)-Catalyzed Defluorinative Bisarylation of Monofluorodienes with Boronic Acids. [PDF]
Org LettLi M, Tsui GC.
europepmc +1 more source
Cu(ii)-catalyzed C-N coupling of 2-aminobenzothiazoles with boronic acids at room temperature. [PDF]
RSC Adv, 2023 Radhika S, Chandravarkar A, Anilkumar G.
europepmc +1 more source
Advanced Science, EarlyView.A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang +7 more
wiley +1 more source
Synthesis of Secondary Boronates via Deaminative Cross-Coupling of Alkyl Nitroso Carbamates and Boronic Acids. [PDF]
Angew Chem Int Ed EnglPaul S, Brown MK.
europepmc +1 more source
Advanced Science, EarlyView.This work develops a polyrotaxane‐based supramolecular semi‐interpenetrating network electrolyte. Its unique architecture decouples ion transport, achieving high ionic conductivity (0.18 mS cm−1), a superior Li+ transference number (> 0.73), and an extended electrochemical window (> 4.9 V), thereby significantly enhancing the performance of high ...
Tianyi Wang +6 more
wiley +1 more source