Results 221 to 230 of about 15,497 (292)

Lower margins are tied to companies' climate performance rather than to low-carbon assets.

Cell Rep Sustain
Fricaudet M, Parker S, Ameli N, Smith T.
europepmc   +1 more source

Neyman-Pearson Multi-class Classification via Cost-sensitive Learning. [PDF]

J Am Stat Assoc
Tian Y, Feng Y.
europepmc   +1 more source

Joint copula‐based beta regression with covariate‐dependent dispersion for malaria indicators

Canadian Journal of Statistics, EarlyView.
Abstract Malaria surveillance relies on multiple indicators that reflect different aspects of transmission and disease burden, yet these outcomes are often analyzed separately under constant‐variance assumptions. Such approaches may obscure residual dependence and heterogeneity in variability. Using Demographic and Health Survey data from Burkina Faso (
Guanjie Lyu, Cindy Feng
wiley   +1 more source

Analyzing the effects of climate risk on discouraged borrowers: Deciphering the contradictory forces. [PDF]

Risk Anal
Anastasiou D, Ballis A, Kallandranis C, Lakhal F.   +3 more
europepmc   +1 more source

Model‐Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model‐Based Longitudinal HbA1c Meta‐Analysis from EMA Marketing Authorization Applications

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence generation for antihyperglycemic therapies in pediatric type 2 diabetes mellitus (T2DM) remains challenging, with most randomized trials failing to demonstrate statistically significant reductions in glycated hemoglobin (HbA1c), partly due to substantial between‐subject variability.
Pieter J. Colin, Efthymios Manolis, Jeroen V. Koomen   +2 more
wiley   +1 more source

Model‐based clinical pharmacology profiling of subcutaneous nivolumab in renal cell carcinoma: Bridging to alternative dosing regimens and indications

Clinical Pharmacology &Therapeutics, EarlyView.
A novel model‐informed drug development (MIDD) approach was employed to derive the coprimary endpoints (time‐averaged serum concentration over 28 days [Cavgd28] and minimum serum concentration at steady state [Cminss]) of the phase III CheckMate 67T study (NCT04810078).
Yue Zhao, Zheyi Hu, Elizabeth Gibson, Li Zhu, Heather Vezina, Anna G. Kondic   +5 more
wiley   +1 more source

Financing a Private Practice: A Practical Framework for Plastic Surgeons. [PDF]

Plast Reconstr Surg Glob Open
Mosca N, Zeitouni F, Tierney M, Via EC, Wirth PJ, Attaluri PK, Rao VK.   +6 more
europepmc   +1 more source

Considerations for the Integration of Clinical Trials and Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
As clinical decision‐making increasingly moves toward individualized and context‐specific treatment recommendations, reliance on any single evidence source, randomized or observational, may be insufficient. Principled integration of randomized controlled trials and real‐world data, grounded in explicit causal frameworks, offers a path toward evidence ...
Sky Qiu, Charles E. Barr, Lauren Dang, Larry Han, Kajsa Kvist, Hana Lee, Andrew Mertens, Nerissa Nance, Lei Nie, Kara Rudolph, Xu Shi, Jens Tarp, Salina P. Waddy, Kenneth Wiley, Andy Wilson, Margot Lisa Jing Yann, Zhiwei Zhang, Tianyue Zhou, Maya Petersen, Mark van der Laan   +19 more
wiley   +1 more source

Overview of Regulatory Guidelines Related to Methods and Models for Small Populations

Clinical Pharmacology &Therapeutics, EarlyView.
This paper provides an overview of approaches and related guidelines from the EMA, FDA, and ICH that are relevant for obtaining clinical evidence for small populations to support regulatory decision making. The approaches are grouped into three categories: (1) maximizing the attainable sample size, (2) adapting the trial design to deal with a small ...
Laurens Sluijterman, Letao Li, Kristin E. Karlsson, Vincent Damotte, Sarah Zohar, Kit Roes, Joanna IntHout   +6 more
wiley   +1 more source